Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers

Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasi...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in immunology Vol. 11; p. 630139
Main Authors:	Hendaoui, Ismaïl, Lahmar, Ahlem, Campo, Luca, Mebarki, Sihem, Bichet, Sandrine, Hess, Daniel, Degen, Martin, Kchir, Nidhameddine, Charrada-Ben Farhat, Leila, Hefaiedh, Rania, Ruiz, Christian, Terracciano, Luigi M, Tucker, Richard P, Hendaoui, Lotfi, Chiquet-Ehrismann, Ruth
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 22-02-2021
Subjects:	extracellular matrix gallbladder cancer Immunology tenascin-C tenascin-N tenascin-W tumor stroma tenascin-C gallbladder cancer tumor stroma tenascin-N tenascin-W extracellular matrix
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils . Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies.
AbstractList	Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils in vitro . Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies. Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils . Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies. Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils in vitro. Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies.
Author	Hendaoui, Ismaïl Bichet, Sandrine Lahmar, Ahlem Mebarki, Sihem Hess, Daniel Degen, Martin Charrada-Ben Farhat, Leila Campo, Luca Terracciano, Luigi M Tucker, Richard P Hendaoui, Lotfi Chiquet-Ehrismann, Ruth Ruiz, Christian Kchir, Nidhameddine Hefaiedh, Rania
AuthorAffiliation	2 Department of Pathology, Mongi Slim University Hospital , La Marsa , Tunisia 1 Friedrich Miescher Institute for Biomedical Research , Basel , Switzerland 5 Pathology Department, La Rabta University Hospital , Tunis , Tunisia 3 Medical School, University of Tunis El Manar , Tunis , Tunisia 8 Institute of Pathology, University Hospital Basel , Basel , Switzerland 6 Department of Diagnostic and Interventional Radiology, Mongi Slim University Hospital , La Marsa , Tunisia 10 Faculty of Science, University of Basel , Basel , Switzerland 4 Laboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics, University of Bern , Bern , Switzerland 7 Department of Hepato-gastro-enterology, Mongi Slim University Hospital , Tunis , Tunisia 9 Department of Cell Biology and Human Anatomy, University of California at Davis , Davis, CA , United States
AuthorAffiliation_xml	– name: 8 Institute of Pathology, University Hospital Basel , Basel , Switzerland – name: 9 Department of Cell Biology and Human Anatomy, University of California at Davis , Davis, CA , United States – name: 1 Friedrich Miescher Institute for Biomedical Research , Basel , Switzerland – name: 4 Laboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics, University of Bern , Bern , Switzerland – name: 6 Department of Diagnostic and Interventional Radiology, Mongi Slim University Hospital , La Marsa , Tunisia – name: 2 Department of Pathology, Mongi Slim University Hospital , La Marsa , Tunisia – name: 5 Pathology Department, La Rabta University Hospital , Tunis , Tunisia – name: 3 Medical School, University of Tunis El Manar , Tunis , Tunisia – name: 10 Faculty of Science, University of Basel , Basel , Switzerland – name: 7 Department of Hepato-gastro-enterology, Mongi Slim University Hospital , Tunis , Tunisia
Author_xml	– sequence: 1 givenname: Ismaïl surname: Hendaoui fullname: Hendaoui, Ismaïl organization: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland – sequence: 2 givenname: Ahlem surname: Lahmar fullname: Lahmar, Ahlem organization: Medical School, University of Tunis El Manar, Tunis, Tunisia – sequence: 3 givenname: Luca surname: Campo fullname: Campo, Luca organization: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland – sequence: 4 givenname: Sihem surname: Mebarki fullname: Mebarki, Sihem organization: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland – sequence: 5 givenname: Sandrine surname: Bichet fullname: Bichet, Sandrine organization: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland – sequence: 6 givenname: Daniel surname: Hess fullname: Hess, Daniel organization: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland – sequence: 7 givenname: Martin surname: Degen fullname: Degen, Martin organization: Laboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland – sequence: 8 givenname: Nidhameddine surname: Kchir fullname: Kchir, Nidhameddine organization: Pathology Department, La Rabta University Hospital, Tunis, Tunisia – sequence: 9 givenname: Leila surname: Charrada-Ben Farhat fullname: Charrada-Ben Farhat, Leila organization: Department of Diagnostic and Interventional Radiology, Mongi Slim University Hospital, La Marsa, Tunisia – sequence: 10 givenname: Rania surname: Hefaiedh fullname: Hefaiedh, Rania organization: Department of Hepato-gastro-enterology, Mongi Slim University Hospital, Tunis, Tunisia – sequence: 11 givenname: Christian surname: Ruiz fullname: Ruiz, Christian organization: Institute of Pathology, University Hospital Basel, Basel, Switzerland – sequence: 12 givenname: Luigi M surname: Terracciano fullname: Terracciano, Luigi M organization: Institute of Pathology, University Hospital Basel, Basel, Switzerland – sequence: 13 givenname: Richard P surname: Tucker fullname: Tucker, Richard P organization: Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA, United States – sequence: 14 givenname: Lotfi surname: Hendaoui fullname: Hendaoui, Lotfi organization: Department of Diagnostic and Interventional Radiology, Mongi Slim University Hospital, La Marsa, Tunisia – sequence: 15 givenname: Ruth surname: Chiquet-Ehrismann fullname: Chiquet-Ehrismann, Ruth organization: Faculty of Science, University of Basel, Basel, Switzerland
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33692777$$D View this record in MEDLINE/PubMed
BookMark	eNpVkU1v1DAQhi1UREvpD-CCcuSSxfYkdnwACVZ8rFTgwCKO1sSeFJfEbu1sJf492W6pWl9s2e88M9bznB3FFImxl4KvADrzZgjTtFtJLvlKARdgnrAToVRTg5TN0YPzMTsr5ZIvqzEA0D5jxwDKSK31CXu7pYjFhVj_qjalwupbuqGx-jHnNOFYfcX8h3IVYvUhjAHz32qb0c3VGqOjXF6wpwOOhc7u9lP289PH7fpLff7982b9_rx2jWrnugGFHnukFnrVCe0RBPXCuU61XYcd-GYwondmMCQQek2OpDdaLZ9D0Ug4ZZsD1ye8tFc5TMsoNmGwtxcpX1jMc3AjWd1K4frBLw11Iz0Z5alFUAuGFHd71rsD62rXT-QdxTnj-Aj6-CWG3_Yi3VhtQCuhF8DrO0BO1zsqs51CcTSOGCntipUt50uyVWaJikPU5VRKpuG-jeB2b9HeWrR7i_Zgcal59XC--4r_zuAf78CayA
CitedBy_id	crossref_primary_10_3389_fonc_2022_908247 crossref_primary_10_20517_2394_5079_2023_23 crossref_primary_10_3389_fimmu_2021_635166
Cites_doi	10.1002/cncr.22815 10.1007/s00018-011-0783-6 10.2353/ajpath.2006.050464 10.1007/s00441-008-0715-4 10.1016/j.canlet.2006.02.017 10.1158/0008-5472.CAN-07-0666 10.1002/1097-0142(19920915)70:6<1498::aid-cncr2820700609>3.0.co;2-c 10.1096/fj.09-140491 10.1080/19336918.2015.1008332 10.1101/cshperspect.a004960 10.1186/1471-2407-14-637 10.1186/1471-2148-6-60 10.1242/jcs.190546 10.1016/j.bbadis.2017.08.027 10.1079/JOH2002129 10.1111/j.1440-1827.2005.01891.x 10.1038/sj.onc.1208342 10.1097/01.MP.0000086860.65672.73 10.1001/archsurg.2009.46 10.1242/jcs.00867 10.1016/j.biocel.2010.06.004 10.1111/j.1741-4520.2009.00227.x 10.3748/wjg.v12.i39.6316 10.1007/BF01851205 10.1186/1472-6890-12-14 10.1002/hep.510270328 10.4143/crt.2017.279 10.1016/j.ajpath.2016.10.021 10.1002/ijc.2910610402 10.1016/j.bbadis.2017.08.002 10.1158/2326-6066.CIR-20-0074 10.3389/fcell.2019.00053 10.2147/CLEP.S37357 10.1002/hep.1840150526 10.1002/ijc.29565 10.1111/j.1600-0676.1992.tb00548.x 10.1016/j.ccr.2011.01.020 10.1002/ijc.23417 10.1002/ijc.21683 10.1158/0008-5472.CAN-12-2130 10.1038/s41467-017-01718-7 10.1159/000207506 10.1111/j.1365-2559.1994.tb01570.x 10.1080/19336918.2015.1008331 10.1016/j.scr.2013.12.006 10.1016/S1044-7431(03)00012-5 10.1007/BF00191347 10.1016/j.matbio.2014.01.007 10.1002/dvdy.20731 10.1136/jnnp.57.10.1212
ContentType	Journal Article
Copyright	Copyright © 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann. Copyright © 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann
Copyright_xml	– notice: Copyright © 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann. – notice: Copyright © 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann
DBID	NPM AAYXX CITATION 7X8 5PM DOA
DOI	10.3389/fimmu.2020.630139
DatabaseName	PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals
DatabaseTitle	PubMed CrossRef MEDLINE - Academic
DatabaseTitleList	CrossRef PubMed MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1664-3224
EndPage	630139
ExternalDocumentID	oai_doaj_org_article_7521cbfdada742de96de5a36142e60c2 10_3389_fimmu_2020_630139 33692777
Genre	Journal Article
GroupedDBID	53G 5VS 9T4 AAFWJ AAKDD ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK EBS EMOBN GROUPED_DOAJ GX1 HYE IAO IEA IHR IHW IPNFZ KQ8 M48 M~E NPM OK1 PGMZT RIG RNS RPM AAYXX CITATION 7X8 5PM
ID	FETCH-LOGICAL-c465t-436adabae53b6817da31eb1cc86588a83d4f91bc9f9e1a3b7ece2d976020a1423
IEDL.DBID	RPM
ISSN	1664-3224
IngestDate	Tue Oct 22 15:09:26 EDT 2024 Tue Sep 17 21:17:58 EDT 2024 Sat Oct 26 00:03:18 EDT 2024 Thu Nov 21 22:58:40 EST 2024 Sat Sep 28 08:32:20 EDT 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	tenascin-C gallbladder cancer tumor stroma tenascin-N tenascin-W extracellular matrix
Language	English
License	Copyright © 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c465t-436adabae53b6817da31eb1cc86588a83d4f91bc9f9e1a3b7ece2d976020a1423
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors share senior authorship Edited by: Kyoko Imanaka-Yoshida, Mie University, Japan Reviewed by: Kenichiro Ishii, Mie University, Japan; Takuya Iyoda, Sanyo-Onoda City University, Japan Deceased This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937617/
PMID	33692777
PQID	2500376569
PQPubID	23479
PageCount	1
ParticipantIDs	doaj_primary_oai_doaj_org_article_7521cbfdada742de96de5a36142e60c2 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7937617 proquest_miscellaneous_2500376569 crossref_primary_10_3389_fimmu_2020_630139 pubmed_primary_33692777
PublicationCentury	2000
PublicationDate	2021-02-22
PublicationDateYYYYMMDD	2021-02-22
PublicationDate_xml	– month: 02 year: 2021 text: 2021-02-22 day: 22
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland
PublicationTitle	Frontiers in immunology
PublicationTitleAlternate	Front Immunol
PublicationYear	2021
Publisher	Frontiers Media S.A
Publisher_xml	– name: Frontiers Media S.A
References	Lowy (B16) 2015; 9 Brellier (B19) 2012; 12 Nagorney (B10) 1988; 15 Kayahara (B8) 2007; 110 Henson (B3); 70 Bourgine (B36) 2014; 12 Chiquet-Ehrismann (B12) 2011; 3 Couvelard (B45) 1998; 27 Meloty-Kapella (B47) 2008; 334 Sithithaworn (B33) 2002; 76 Mertens (B1) 2018; 1864 Chiquet-Ehrismann (B23) 2014; 37 Orend (B14) 2006; 244 Yoshida (B42) 1994; 57 Konstantinidis (B5) 2009; 144 Shimizu (B51) 2006; 12 Alvaro (B50) 2006; 169 Chiovaro (B34) 2015; 137 de Aretxabala (B6) 1995; 123 Degen (B28) 2008; 122 Scherberich (B26) 2005; 24 Degen (B27) 2007; 67 Terada (B37) 1994; 25 Zuliani-Alvarez (B53) 2017; 8 Randi (B4) 2006; 118 Tucker (B11) 2006; 6 Midwood (B13) 2016; 129 Bosman (B30) 2010 Quante (B35) 2011; 19 Martina (B29) 2010; 24 Yoshida (B17) 2015; 9 Martina (B20) 2010; 42 Okamura (B39) 2005; 55 Scherberich (B25) 2004; 117 Meloty-Kapella (B22) 2006; 235 Ehrlich (B52) 2017; 187 Mertens (B40) 2013; 73 Macias (B46) 2018; 1864 Hundal (B2) 2014; 6 Neidhardt (B24) 2003; 23 Schenk (B31) 1995; 61 Heike (B32) 1995; 426 Kusaka (B49) 1988; 188 Van Eyken (B43) 1992; 15 Hamdi-Cherif (B9) 2014; 14 Tucker (B21) 2019; 7 Spenlé (B18) 2020; 8 Mikura (B48) 2009; 49 Midwood (B15) 2011; 68 Aishima (B38) 2003; 16 Yamada (B44) 1992; 12 Wi (B7) 2018; 50 Iguchi (B41) 2009; 76
References_xml	– volume: 110 year: 2007 ident: B8 article-title: Recent trends of gallbladder cancer in Japan: an analysis of 4,770 patients publication-title: Cancer doi: 10.1002/cncr.22815 contributor: fullname: Kayahara – volume: 68 year: 2011 ident: B15 article-title: Advances in tenascin-C biology publication-title: Cell Mol Life Sci doi: 10.1007/s00018-011-0783-6 contributor: fullname: Midwood – volume: 169 year: 2006 ident: B50 article-title: Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma publication-title: Am J Pathol doi: 10.2353/ajpath.2006.050464 contributor: fullname: Alvaro – volume: 334 year: 2008 ident: B47 article-title: Effects of tenascin-W on osteoblasts in vitro publication-title: Cell Tissue Res doi: 10.1007/s00441-008-0715-4 contributor: fullname: Meloty-Kapella – volume: 244 year: 2006 ident: B14 article-title: Tenascin-C induced signaling in cancer publication-title: Cancer Lett doi: 10.1016/j.canlet.2006.02.017 contributor: fullname: Orend – volume: 67 year: 2007 ident: B27 article-title: Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0666 contributor: fullname: Degen – volume: 70 ident: B3 article-title: Carcinoma of the gallbladder. (1992). Histologic types, stage of disease, grade, and survival rates publication-title: Cancer doi: 10.1002/1097-0142(19920915)70:6<1498::aid-cncr2820700609>3.0.co;2-c contributor: fullname: Henson – volume: 24 year: 2010 ident: B29 article-title: Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro publication-title: FASEB J doi: 10.1096/fj.09-140491 contributor: fullname: Martina – volume: 9 start-page: 96 year: 2015 ident: B17 article-title: Tenascin-C and integrins in cancer publication-title: Cell Adh Migr doi: 10.1080/19336918.2015.1008332 contributor: fullname: Yoshida – volume: 3 year: 2011 ident: B12 article-title: Tenascins and the importance of adhesion modulation publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a004960 contributor: fullname: Chiquet-Ehrismann – volume: 14 year: 2014 ident: B9 article-title: Time trends of cancer incidence in Setif, Algeria, 1986-2010: an observational study publication-title: BMC Cancer doi: 10.1186/1471-2407-14-637 contributor: fullname: Hamdi-Cherif – volume: 6 year: 2006 ident: B11 article-title: Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage publication-title: BMC Evol Biol doi: 10.1186/1471-2148-6-60 contributor: fullname: Tucker – volume: 129 year: 2016 ident: B13 article-title: Tenascin-C at a glance publication-title: J Cell Sci doi: 10.1242/jcs.190546 contributor: fullname: Midwood – volume: 1864 year: 2018 ident: B1 article-title: Targeting cholangiocarcinoma publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2017.08.027 contributor: fullname: Mertens – volume: 76 year: 2002 ident: B33 article-title: Expression of tenascin in bile duct cancer of hamster liver by combined treatment of dimethylnitrosamine with Opisthorchis viverrini infections publication-title: J Helminthol doi: 10.1079/JOH2002129 contributor: fullname: Sithithaworn – volume: 55 year: 2005 ident: B39 article-title: Cellular and stromal characteristics in the scirrhous hepatocellular carcinoma: comparison with hepatocellular carcinomas and intrahepatic cholangiocarcinomas publication-title: Pathol Int doi: 10.1111/j.1440-1827.2005.01891.x contributor: fullname: Okamura – volume: 24 year: 2005 ident: B26 article-title: Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro publication-title: Oncogene doi: 10.1038/sj.onc.1208342 contributor: fullname: Scherberich – volume: 16 year: 2003 ident: B38 article-title: Tenascin expression at the invasive front is associated with poor prognosis in intrahepatic cholangiocarcinoma publication-title: Mod Pathol doi: 10.1097/01.MP.0000086860.65672.73 contributor: fullname: Aishima – volume: 144 year: 2009 ident: B5 article-title: Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience publication-title: Arch Surg doi: 10.1001/archsurg.2009.46 contributor: fullname: Konstantinidis – volume-title: WHO classification of tumours of the digestive system year: 2010 ident: B30 contributor: fullname: Bosman – volume: 117 year: 2004 ident: B25 article-title: Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development publication-title: J Cell Sci doi: 10.1242/jcs.00867 contributor: fullname: Scherberich – volume: 42 year: 2010 ident: B20 article-title: Tenascin-W: an extracellular matrix protein associated with osteogenesis and cancer publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2010.06.004 contributor: fullname: Martina – volume: 49 start-page: 77 year: 2009 ident: B48 article-title: Association of tenascin-W expression with mineralization in mouse calvarial development publication-title: Congenit Anom (Kyoto) doi: 10.1111/j.1741-4520.2009.00227.x contributor: fullname: Mikura – volume: 12 year: 2006 ident: B51 article-title: Effect of transforming growth factor-beta1 on human intrahepatic cholangiocarcinoma cell growth publication-title: World J Gastroenterol doi: 10.3748/wjg.v12.i39.6316 contributor: fullname: Shimizu – volume: 188 year: 1988 ident: B49 article-title: Establishment and characterization of a cell line from a human cholangiocellular carcinoma publication-title: Res Exp Med (Berl) doi: 10.1007/BF01851205 contributor: fullname: Kusaka – volume: 12 start-page: 14 year: 2012 ident: B19 article-title: Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors publication-title: BMC Clin Pathol doi: 10.1186/1472-6890-12-14 contributor: fullname: Brellier – volume: 27 year: 1998 ident: B45 article-title: Expression of integrins during liver organogenesis in humans publication-title: Hepatology doi: 10.1002/hep.510270328 contributor: fullname: Couvelard – volume: 50 year: 2018 ident: B7 article-title: Trends in gallbladder cancer incidence and survival in Korea publication-title: Cancer Res Treat doi: 10.4143/crt.2017.279 contributor: fullname: Wi – volume: 187 year: 2017 ident: B52 article-title: miR-24 Inhibition increases menin expression and decreases cholangiocarcinoma proliferation publication-title: Am J Pathol doi: 10.1016/j.ajpath.2016.10.021 contributor: fullname: Ehrlich – volume: 61 year: 1995 ident: B31 article-title: Tenascin-C in serum: a questionable tumor marker publication-title: Int J Cancer doi: 10.1002/ijc.2910610402 contributor: fullname: Schenk – volume: 1864 year: 2018 ident: B46 article-title: The search for novel diagnostic and prognostic biomarkers in cholangiocarcinoma publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2017.08.002 contributor: fullname: Macias – volume: 8 year: 2020 ident: B18 article-title: Tenascin-C orchestrates an immune suppressive tumor microenvironment in oral squamous cell carcinoma publication-title: Cancer Immunol Res doi: 10.1158/2326-6066.CIR-20-0074 contributor: fullname: Spenlé – volume: 7 year: 2019 ident: B21 article-title: The expression and possible functions of tenascin-W during development and disease publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2019.00053 contributor: fullname: Tucker – volume: 6 start-page: 99 year: 2014 ident: B2 article-title: Gallbladder cancer: epidemiology and outcome publication-title: Clin Epidemiol doi: 10.2147/CLEP.S37357 contributor: fullname: Hundal – volume: 15 year: 1992 ident: B43 article-title: Localization and cellular source of the extracellular matrix protein tenascin in normal and fibrotic rat liver publication-title: Hepatology doi: 10.1002/hep.1840150526 contributor: fullname: Van Eyken – volume: 137 year: 2015 ident: B34 article-title: Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells publication-title: Int J Cancer doi: 10.1002/ijc.29565 contributor: fullname: Chiovaro – volume: 123 year: 1995 ident: B6 article-title: Gallbladder cancer. Case-control study publication-title: Rev Med Chil contributor: fullname: de Aretxabala – volume: 12 year: 1992 ident: B44 article-title: Tenascin expression in human chronic liver disease and in hepatocellular carcinoma publication-title: Liver doi: 10.1111/j.1600-0676.1992.tb00548.x contributor: fullname: Yamada – volume: 19 year: 2011 ident: B35 article-title: Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.01.020 contributor: fullname: Quante – volume: 122 year: 2008 ident: B28 article-title: Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients publication-title: Int J Cancer doi: 10.1002/ijc.23417 contributor: fullname: Degen – volume: 118 year: 2006 ident: B4 article-title: Gallbladder cancer worldwide: geographical distribution and risk factors publication-title: Int J Cancer doi: 10.1002/ijc.21683 contributor: fullname: Randi – volume: 73 start-page: 897 year: 2013 ident: B40 article-title: Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-2130 contributor: fullname: Mertens – volume: 8 start-page: 1595 year: 2017 ident: B53 article-title: Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers publication-title: Nat Commun doi: 10.1038/s41467-017-01718-7 contributor: fullname: Zuliani-Alvarez – volume: 76 start-page: 293 year: 2009 ident: B41 article-title: A comprehensive analysis of immunohistochemical studies in intrahepatic cholangiocarcinoma using the survival tree model publication-title: Oncology doi: 10.1159/000207506 contributor: fullname: Iguchi – volume: 25 year: 1994 ident: B37 article-title: Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in intrahepatic cholangiocarcinoma publication-title: Histopathology doi: 10.1111/j.1365-2559.1994.tb01570.x contributor: fullname: Terada – volume: 15 year: 1988 ident: B10 article-title: Carcinoma of the gallbladder and extrahepatic bile ducts publication-title: Semin Oncol contributor: fullname: Nagorney – volume: 9 year: 2015 ident: B16 article-title: Tenascin C in metastasis: A view from the invasive front publication-title: Cell Adh Migr doi: 10.1080/19336918.2015.1008331 contributor: fullname: Lowy – volume: 12 year: 2014 ident: B36 article-title: Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival publication-title: Stem Cell Res doi: 10.1016/j.scr.2013.12.006 contributor: fullname: Bourgine – volume: 23 start-page: 193 year: 2003 ident: B24 article-title: Tenascin-N: characterization of a novel member of the tenascin family that mediates neurite repulsion from hippocampal explants publication-title: Mol Cell Neurosci doi: 10.1016/S1044-7431(03)00012-5 contributor: fullname: Neidhardt – volume: 426 year: 1995 ident: B32 article-title: New cell lines of gastric and pancreatic cancer: distinct morphology, growth characteristics, expression of epithelial and immunoregulatory antigens publication-title: Virchows Arch doi: 10.1007/BF00191347 contributor: fullname: Heike – volume: 37 year: 2014 ident: B23 article-title: Tenascins in stem cell niches publication-title: Matrix Biol doi: 10.1016/j.matbio.2014.01.007 contributor: fullname: Chiquet-Ehrismann – volume: 235 year: 2006 ident: B22 article-title: Avian tenascin-W: expression in smooth muscle and bone, and effects on calvarial cell spreading and adhesion in vitro publication-title: Dev Dyn doi: 10.1002/dvdy.20731 contributor: fullname: Meloty-Kapella – volume: 57 year: 1994 ident: B42 article-title: Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.57.10.1212 contributor: fullname: Yoshida
SSID	ssj0000493335
Score	2.3315094
Snippet	Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined...
SourceID	doaj pubmedcentral proquest crossref pubmed
SourceType	Open Website Open Access Repository Aggregation Database Index Database
StartPage	630139
SubjectTerms	extracellular matrix gallbladder cancer Immunology tenascin-C tenascin-N tenascin-W tumor stroma
SummonAdditionalLinks	– databaseName: Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA4qCF7Et-uLCJ6Eatu0eRw8-EQvXlzRW0iTKVZ2u9LdFfz3Tpp1cUXw4jVtSfpNmvmmyXxDyBG6XCQWLonygrEo44WvBihUpJzMC2zLMuv_d9w-iPtneXXtZXKmpb78mbAgDxyAOxXoX2xROuMMRnEOFHeQG4ZeJQUe27D6xvxbMPUaeC9jLA_bmBiFqdOy6vfHGA-m8QlnnvfMOKJWr_83kvnzrOQ353OzQpYnrJGeh9Gukjmo18hiqCP5sU7OulAb9GV19ETvhtTQ-8E79OjDqBn08TGfjwMNrWp6UfUq03zQrs-Nopfe4s1wgzzeXHcvb6NJXYTIZjwfRRnjiEZhIGcFl4lwhiW45ForkU5II5nLSpUUVpUKEsMKARZSh7wDX94gbmyTLNSDGrYJxe8ZGV0iEWCZ2VQaaAUGS8tjACXSDjn-Akm_BfkLjWGDR1S3iGqPqA6IdsiFh3F6o1eubhvQnnpiT_2XPTvk8MsIGme6374wNQzGQ41kLcblMOfY0VYwyrQrxrhKhRAdImbMNTOW2St19dKqaXuBQKRxO_8x-F2ylPozLz7lPd0jC6NmDPtkfujGB-38_ATTU-mx priority: 102 providerName: Directory of Open Access Journals
Title	Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers
URI	https://www.ncbi.nlm.nih.gov/pubmed/33692777 https://search.proquest.com/docview/2500376569 https://pubmed.ncbi.nlm.nih.gov/PMC7937617 https://doaj.org/article/7521cbfdada742de96de5a36142e60c2
Volume	11
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6xlUC9oPLsUqiMxAkpu5s4sZ0DB7q0KgcqpC6Cm-VXINXGqbK7lfrvO3Y2VRdx4urEGme-SeabeGYM8AFdLhILmyaFpjTJmQ6nAfIyKa0oNI7luQn_O84v-cUv8eU0tMkphlqYmLRvdD3xy2bi6z8xt_K6MdMhT2z6_ds89HRDzzsdwQi54YMQ_aqnvJTSot_BxACsnFZ102wwFMxmE0YD5dmHJ5SyMuOc77ij2LX_X1Tz74zJBy7o7ACebrkj-dyv8Rk8cv45PO5Pk7x9AZ8Wziv0aD75Sb6uiCIX7Y1bkst11zY4LVTluI7UnpzUy1p1t2QRKqTIPODerV7Cj7PTxfw82Z6OkJicFeskp0xZpZUrqGYi5VbRFD-8xggkFUIJavOqTLUpq9KlimrujMsssg_Ug0qRRb2CPd96dwgE32rkdanQlRW5yYRysc1gZdjMuZJnY_g4KEle900wJAYPQbkyKlcG5cpeuWM4CWq8vzH0r44DbfdbblGUHFmDQXH4BBibW5RnXaEocoXMsZlBie8HECTae9jEUN61m5VEyjZD9AuGgl73oNyLGkAdA9-Ba2ctu1fQxGJP7a1JvfnvmUewn4V0l1Dtnr2FvXW3ce9gtLKb4xjnH0crvQM3tup6
link.rule.ids	230,315,729,782,786,866,887,2106,27933,27934,53800,53802
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB7RIqAXnoVuy8NInJCym8RJ7Bw4tEurrWhXSF0EN8uvQNDGqbK7lfrvO042VRdx6jWONc58tuebeGYM8AlNLhILEwWpojRIMuVvA2R5kBueKnyWJNr_75hcsOkv_vXYl8lJ-1yYNmhfq3Lo5tXQlX_a2MrLSo_6OLHR9_Oxr-mGlne0BQ9xvYbhHSf9b0d6KaVpd4aJLlg-KsqqWqEzGIfDjHrSswOPKc3ymDG2YZDauv3_I5v_xkzeMUInz-45_OfwdM06yWHX_AIeWPcSHnX3UF6_gi8z6yTaQhf8JKcLIsm0vrJzcrFs6gq7-Xwe25DSkaNyXsrmmsx8bhUZ-xnTLHbhx8nxbDwJ1vcqBDrJ0mWQ0EwaqaRNqcp4xIykEW7ZWnOkI1xyapIij5TOi9xGkipmtY0N8hbUn4yQf72GbVc7uwcE9wNkhBFXheGJjrm0bYHCQmehtTmLB_C5V6647MpnCHQ7PCiiBUV4UEQHygCOvPpvX_SVr9sHdfNbrBUoGPINjeLwC9CrNyjP2FRSZBmxzUKNEj_24AlcKf74QzpbrxYCyV6Iik8zFPSmA_NWVD8ZBsA2YN4Yy2YLottW416juX_vnh_gyWR2fibOTqffDmAn9kEzPmc-fgvby2Zl38HWwqzet3P8BpXA_xU
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYENNexudY-TQST0hpEjuxnQceWLdqE1BNWhG8Wf4KBDVOlbZI--85J221Ip7gNbF18f1s3-_i8x1Cb8HkArGwaZRrSqOM6VANkBdRYUWu4VmWmfC_4-KaT76Js_OQJmdb6qsL2je6GvpZPfTVjy62cl6beBMnFl99HoWcbmB547kt4z10F9ZsQm456j974kspzftzTHDDiris6noFDiFJhowG4nOIDihlBeGc7xilLnf_3wjnn3GTtwzR-P5_DOEBOlqzT_yhb_IQ3XH-EbrX16O8eYzeT51XYBN99BVfLrDCk-aXm-HrZdvU0C3c63Etrjw-rWaVam_wNNyxwqMwc9rFE_RlfD4dXUTr-gqRyVi-jDLKlFVauZxqJlJuFU1h6zZGAC0RSlCblUWqTVEWLlVUc2ccscBfQIcqBR52jPZ9490JwrAvADNMhS6tyAwRynWJCkvDEucKTgbo3UbBct6n0ZDgfgRgZAeMDMDIHpgBOg0QbBuGDNjdg6b9LtdKlBx4hwFxMALw7i3Isy5XFNgGcSwxIPHNBkAJKyYcgyjvmtVCAulLQPk5A0FPe0C3ojYTYoD4DtQ737L7BhDusnKvEX32zz1fo4Ors7H8dDn5-BwdkhA7E67Okxdof9mu3Eu0t7CrV900_w2riAGk
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tenascin-W+Is+a+Novel+Stromal+Marker+in+Biliary+Tract+Cancers&rft.jtitle=Frontiers+in+immunology&rft.au=Hendaoui%2C+Isma%C3%AFl&rft.au=Lahmar%2C+Ahlem&rft.au=Campo%2C+Luca&rft.au=Mebarki%2C+Sihem&rft.date=2021-02-22&rft.eissn=1664-3224&rft.volume=11&rft.spage=630139&rft.epage=630139&rft_id=info:doi/10.3389%2Ffimmu.2020.630139&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-3224&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-3224&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-3224&client=summon