Inference of COVID-19 epidemiological distributions from Brazilian hospital data

• Published in: Journal of the Royal Society interface Vol. 17; no. 172; p. 20200596
• Main Authors: Hawryluk, Iwona, Mellan, Thomas A, Hoeltgebaum, Henrique, Mishra, Swapnil, Schnekenberg, Ricardo P, Whittaker, Charles, Zhu, Harrison, Gandy, Axel, Donnelly, Christl A, Flaxman, Seth, Bhatt, Samir
• Format: Journal Article
• Language: English
• Published: England The Royal Society 01-11-2020
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Bayes Theorem; Brazil - epidemiology; Child; Child, Preschool; COVID-19 - epidemiology; COVID-19 - mortality; Female; Hospitalization - statistics & numerical data; Hospitals - statistics & numerical data; Humans; Infant; Infant, Newborn; Life Sciences–Mathematics interface; Male; Middle Aged; Models, Statistical; Pandemics - statistics & numerical data; Poverty; Probability; SARS-CoV-2; Time Factors; Young Adult; Brazil; COVID-19; Brazil; model selection; admission-to-death; symptom-onset-to-death
• ISSN: 1742-5689; 1742-5662
• DOI: 10.1098/rsif.2020.0596

Knowing COVID-19 epidemiological distributions, such as the time from patient admission to death, is directly relevant to effective primary and secondary care planning, and moreover, the mathematical modelling of the pandemic generally. We determine epidemiological distributions for patients hospitalized with COVID-19 using a large dataset (
= 21 000 - 157 000) from the Brazilian Sistema de Informação de Vigilância Epidemiológica da Gripe database. A joint Bayesian subnational model with partial pooling is used to simultaneously describe the 26 states and one federal district of Brazil, and shows significant variation in the mean of the symptom-onset-to-death time, with ranges between 11.2 and 17.8 days across the different states, and a mean of 15.2 days for Brazil. We find strong evidence in favour of specific probability density function choices: for example, the gamma distribution gives the best fit for onset-to-death and the generalized lognormal for onset-to-hospital-admission. Our results show that epidemiological distributions have considerable geographical variation, and provide the first estimates of these distributions in a low and middle-income setting. At the subnational level, variation in COVID-19 outcome timings are found to be correlated with poverty, deprivation and segregation levels, and weaker correlation is observed for mean age, wealth and urbanicity.