Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents

• Published in: Genetics and molecular biology Vol. 41; no. 4; pp. 735 - 741
• Main Authors: Gasparin, Caroline C, Leite, Neiva, Tureck, Luciane V, Souza, Ricardo L R, Milano-Gai, Gerusa E, Silva, Larissa R, Lopes, Wendell A, Furtado-Alle, Lupe
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Genetica 01-10-2018; Sociedade Brasileira de Genética
• Subjects: ADIPOQ gene; Adolescents; Alleles; Anthropometry; APOB gene; APOE gene; Apolipoprotein E; BIOCHEMISTRY & MOLECULAR BIOLOGY; Children; Cholesterol; Density; Deoxyribonucleic acid; DNA; Genes; Genetic diversity; Genetic variance; GENETICS & HEREDITY; High density lipoprotein; HSD11β1 gene; Human and Medical Genetics; Lipids; Low density lipoprotein; Obesity; PLIN4 gene; Risk analysis; Risk factors; Weight; ADIPOQ gene; HSD11β1 gene; APOE gene; PLIN4 gene; APOB gene
• ISSN: 1415-4757; 1678-4685; 1678-4685
• DOI: 10.1590/1678-4685-gmb-2017-0195

Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life.