Sphingosine 1‐phosphate is a ligand for peroxisome proliferator‐activated receptor‐γ that regulates neoangiogenesis

ABSTRACT Sphingosine 1‐phosphate (S1P) is a bio‐active lipid that can function both extracellularly and intracellularly to mediate a variety of cellular processes. Using lipid affinity matrices and a radiolabeled lipid binding assay, we reveal that S1P directly interacts with the transcription facto...

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Bibliographic Details
Published in:	The FASEB journal Vol. 29; no. 9; pp. 3638 - 3653
Main Authors:	Parham, Kate A., Zebol, Julia R., Tooley, Katie L., Sun, Wai Y., Moldenhauer, Lachlan M., Cockshell, Michaelia P., Gliddon, Briony L., Moretti, Paul A., Tigyi, Gabor, Pitson, Stuart M., Bonder, Claudine S.
Format:	Journal Article
Language:	English
Published:	United States The Federation of American Societies for Experimental Biology 01-09-2015 Federation of American Societies for Experimental Biology
Subjects:	actor Animals Carrier Proteins - genetics Carrier Proteins - metabolism CD36 Antigens - genetics CD36 Antigens - metabolism endothelial HEK293 Cells Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans Lysophospholipids - genetics Lysophospholipids - metabolism Mice Mice, Knockout neovascularization Neovascularization, Physiologic - physiology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism PPAR gamma - genetics PPAR gamma - metabolism Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism Research Communication Serpin E2 - genetics Serpin E2 - metabolism Sphingosine - analogs & derivatives Sphingosine - genetics Sphingosine - metabolism transcription Transcription Factors - genetics Transcription Factors - metabolism U937 Cells transcription factor endothelial neovascularization
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