CCR5delta32 in systemic lupus erythematosus: implications for disease susceptibility and outcome in a Brazilian population

• Published in: Lupus Vol. 22; no. 8; pp. 802 - 809
• Main Authors: Schauren, JS, Marasca, JA, Veit, TD, Monticielo, OA, Xavier, RM, Brenol, JCT, Chies, JAB
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-07-2013; Sage Publications Ltd
• Subjects: Adult; African Continental Ancestry Group; Alleles; Arthritis; Autoimmune diseases; Brazil; Case-Control Studies; Disease; Ethnicity; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genetics; Genotype; HIV; Human immunodeficiency virus; Humans; Infections; Laboratories; Lupus; Lupus Erythematosus, Systemic - genetics; Lupus Nephritis - genetics; Male; Middle Aged; Multivariate Analysis; Polymorphism; Polymorphism, Genetic; Proteins; Receptors, CCR5 - genetics; Rheumatology; Sex Factors; West Nile virus; Brazil; Rio Grande do Sul Brazil; Europe; Autoimmunity; CCR5delta32; lupus nephritis; systemic lupus erythematosus; CCR5
• ISSN: 0961-2033; 1477-0962
• DOI: 10.1177/0961203313491848

The aim of this study was to analyze the allelic and genotypic frequencies of the CCR5delta32 polymorphism in systemic lupus erythematosus (SLE) patients and to investigate a possible association of this allele with SLE susceptibility and clinical outcome. A total of 367 SLE patients and 435 healthy controls were genotyped for the CCR5delta32 polymorphism. We observed that, in European-derived individuals, the frequency of the CCR5delta32 allele was smaller in patients than in controls (2.7% vs. 7.5%, OR 0.34, 95% CI 0.17–0.65, p
Bonf = 0.002), suggesting that this allele could be considered a protective factor for the disease. Regarding clinical manifestations, we observed that CCR5delta32 female African-derived carrier patients presented a higher predisposition to class IV nephritis when compared with absent nephritis/other class group (13.8% vs. 3.8%, OR 37.1, 95% CI 2.8–1854.7, p
Bonf = 0.030). A multivariate analysis including all female patients and controlling for the presence or absence of anti-dsDNA antibodies, ethnicity and age at diagnosis showed an increased relative risk of 3.9 times for patients carrying the CCR5delta32 allele to develop class IV nephritis as compared with noncarriers. Our data suggest that the CCR5delta32 allele is a protective factor for the disease in European-derived patients and a susceptibility factor to class IV nephritis in African-derived female patients.