Oral contraceptive effectiveness according to body mass index, weight, age, and other factors
Objective The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other factors. Study Design In a planned secondary analysis, we used data from the European Active Surveillance Study on Oral Contracept...
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| Published in: | American journal of obstetrics and gynecology Vol. 201; no. 3; pp. 263.e1 - 263.e9 |
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| Language: | English |
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| Abstract | Objective The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other factors. Study Design In a planned secondary analysis, we used data from the European Active Surveillance Study on Oral Contraceptives, which was a prospective active cohort surveillance study of 59,510 OC users, to assess the effectiveness of OCs overall and by BMI, weight, age, duration of use, ethinylestradiol dose, regimen type, starting/switching status, and parity. Self-reported unplanned pregnancies during OC use were confirmed by interview. Results An analysis of OC effectiveness (112,659 women-years of exposure and 545 unplanned pregnancies) found little variation in effectiveness by BMI/weight. Failure rates decreased after 30 years of age and with an increasing duration of use. Conclusion OC users in Europe reported high contraceptive effectiveness with “typical use.” Failure rates decreased with age and duration of use. BMI and weight had little, if any, influence on effectiveness. |
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| AbstractList | The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other factors.
In a planned secondary analysis, we used data from the European Active Surveillance Study on Oral Contraceptives, which was a prospective active cohort surveillance study of 59,510 OC users, to assess the effectiveness of OCs overall and by BMI, weight, age, duration of use, ethinylestradiol dose, regimen type, starting/switching status, and parity. Self-reported unplanned pregnancies during OC use were confirmed by interview.
An analysis of OC effectiveness (112,659 women-years of exposure and 545 unplanned pregnancies) found little variation in effectiveness by BMI/weight. Failure rates decreased after 30 years of age and with an increasing duration of use.
OC users in Europe reported high contraceptive effectiveness with "typical use." Failure rates decreased with age and duration of use. BMI and weight had little, if any, influence on effectiveness. Objective The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other factors. Study Design In a planned secondary analysis, we used data from the European Active Surveillance Study on Oral Contraceptives, which was a prospective active cohort surveillance study of 59,510 OC users, to assess the effectiveness of OCs overall and by BMI, weight, age, duration of use, ethinylestradiol dose, regimen type, starting/switching status, and parity. Self-reported unplanned pregnancies during OC use were confirmed by interview. Results An analysis of OC effectiveness (112,659 women-years of exposure and 545 unplanned pregnancies) found little variation in effectiveness by BMI/weight. Failure rates decreased after 30 years of age and with an increasing duration of use. Conclusion OC users in Europe reported high contraceptive effectiveness with “typical use.” Failure rates decreased with age and duration of use. BMI and weight had little, if any, influence on effectiveness. OBJECTIVEThe purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other factors.STUDY DESIGNIn a planned secondary analysis, we used data from the European Active Surveillance Study on Oral Contraceptives, which was a prospective active cohort surveillance study of 59,510 OC users, to assess the effectiveness of OCs overall and by BMI, weight, age, duration of use, ethinylestradiol dose, regimen type, starting/switching status, and parity. Self-reported unplanned pregnancies during OC use were confirmed by interview.RESULTSAn analysis of OC effectiveness (112,659 women-years of exposure and 545 unplanned pregnancies) found little variation in effectiveness by BMI/weight. Failure rates decreased after 30 years of age and with an increasing duration of use.CONCLUSIONOC users in Europe reported high contraceptive effectiveness with "typical use." Failure rates decreased with age and duration of use. BMI and weight had little, if any, influence on effectiveness. |
| Author | Cronin, Maureen, MD, PhD Dinger, Jürgen C., MD, PhD Möhner, Sabine, PhD Minh, Thai Do, PhD Westhoff, Carolyn, MD, MSc Schellschmidt, Ilka, MD |
| Author_xml | – sequence: 1 fullname: Dinger, Jürgen C., MD, PhD – sequence: 2 fullname: Cronin, Maureen, MD, PhD – sequence: 3 fullname: Möhner, Sabine, PhD – sequence: 4 fullname: Schellschmidt, Ilka, MD – sequence: 5 fullname: Minh, Thai Do, PhD – sequence: 6 fullname: Westhoff, Carolyn, MD, MSc |
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| Keywords | oral contraceptives weight contraceptive effectiveness body mass index Body mass index Contraceptive Obstetrics Gynecology Age Oral administration |
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| Snippet | Objective The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age,... The purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age, and other... OBJECTIVEThe purpose of this study was to assess the use-effectiveness of oral contraceptives (OCs) in Europe according to body mass index (BMI), weight, age,... |
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| SubjectTerms | Age Factors Biological and medical sciences Body Mass Index Body Weight contraceptive effectiveness Contraceptives, Oral - pharmacology Europe Female Gynecology. Andrology. Obstetrics Humans Life Tables Medical sciences Obstetrics and Gynecology oral contraceptives Pregnancy, Unplanned Risk Factors Time Factors Treatment Failure weight |
| Title | Oral contraceptive effectiveness according to body mass index, weight, age, and other factors |
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