Pyrazolo[4,3-e][1,2,4]triazines: purine analogues with electronic absorption in the visible region

• Published in: Molecules (Basel, Switzerland) Vol. 10; no. 10; pp. 1298 - 1306
• Main Authors: Mojzych, Mariusz, Rykowski, Andrzej, Wierzchowski, Jacek
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31-10-2005; MDPI
• Subjects: 3-e; 4]triazines; Absorption; Animals; Cattle; Cultured Milk Products - enzymology; Drug Evaluation; enzyme inhibitors; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Enzymes; Escherichia coli - enzymology; Guanine Deaminase - antagonists & inhibitors; Guanine Deaminase - metabolism; Hydrocarbons; Light; Metabolism; Models, Biological; Muscles - enzymology; Oxidation; Potassium; purine analogues; Purine-Nucleoside Phosphorylase - antagonists & inhibitors; Purine-Nucleoside Phosphorylase - metabolism; Purines - chemistry; Purines - metabolism; Purines - pharmacology; Pyrazoles - chemistry; Pyrazoles - pharmacology; Pyrazolo; Rabbits; Triazines - chemistry; Triazines - pharmacology; Xanthine Oxidase - antagonists & inhibitors; Xanthine Oxidase - metabolism; Poland
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/10101298

Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10(-3) -10(-5) M range.