A 42-kD Tyrosine Kinase Substrate Linked to Chromaffin Cell Secretion Exhibits an Associated MAP Kinase Activity and Is Highly Related to a 42-kD Mitogen-Stimulated Protein in Fibroblasts

The localization of the protein tyrosine kinase pp60 c-src to the plasma membrane and to the membrane of secretory vesicles in neurally derived bovine chromaffin cells has suggested that tyrosine phosphorylations may be associated with the process of secretion. In the present study we have identifie...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 110; no. 3; pp. 731 - 742
Main Authors:	Ely, Constance M., Oddie, Karen M., Litz, Julie S., Rossomando, Anthony J., Kanner, Steven B., Sturgill, Thomas W., Parsons, Sarah J.
Format:	Journal Article
Language:	English
Published:	New York, NY Rockefeller University Press 01-03-1990 The Rockefeller University Press
Subjects:	Adipocytes Adrenal Gland Neoplasms Adrenal Medulla - metabolism Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cattle Cell growth Cell Line Cell lines Cells Cells, Cultured Chromaffin cells Cultured cells Cyanogen Bromide Fibroblasts Fundamental and applied biological sciences. Psychology Gels Miscellaneous Molecular Weight Norepinephrine - metabolism Peptide Mapping Pheochromocytoma Phosphoproteins - isolation & purification Phosphorylation Phosphotyrosine plasma membranes Protein-Tyrosine Kinases - metabolism Proteins Proteins - metabolism Secretion Substrate Specificity Tyrosine - analogs & derivatives Tyrosine - analysis Tyrosine Phosphorylation Bovine Gel electrophoresis Enzyme Identification Chromaffin cell Cytosol Ion exchange chromatography Proteins Vertebrata Mammalia Enzymatic activity Protein kinase Artiodactyla Microtubule Localization Ungulata
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