Prolonged Cold Ischemic Times and Less Donor-Recipient Histocompatibility Accelerate Graft Vascular Disease

Abstract Introduction The long-term success of cardiac transplantation is limited by graft atherosclerosis, also known as graft vascular disease (GVD). GVD is currently the leading cause of late allograft failure in cardiac transplant recipients. The aim of this study was to assess the effects of co...

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Bibliographic Details
Published in:	Transplantation proceedings Vol. 43; no. 10; pp. 3863 - 3868
Main Authors:	Czer, L.S.C, Wong, A.V, Soukiasian, H, Gallagher, S, De Robertis, M, Trento, A
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-12-2011 Elsevier
Subjects:	Adenosine - pharmacology Allopurinol - pharmacology Animals Biological and medical sciences Cold Ischemia - adverse effects Coronary Artery Disease - etiology Coronary Artery Disease - immunology Coronary Artery Disease - pathology Coronary Artery Disease - prevention & control Fundamental and applied biological sciences. Psychology Fundamental immunology Glutathione - pharmacology Graft Rejection - etiology Graft Rejection - immunology Heart Transplantation - adverse effects Heart Transplantation - immunology Histocompatibility Histocompatibility Antigens - immunology Insulin - pharmacology Male Medical sciences Organ Preservation Solutions - pharmacology Raffinose - pharmacology Rats Rats, Inbred ACI Rats, Inbred F344 Rats, Inbred Lew Risk Assessment Risk Factors Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Tissue, organ and graft immunology Suboptimal donor Human Medicine Graft vascular disease Treatment Surgery Graft Recipient Transplantation Histocompatibility Hypothermia Prolonged
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