miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle

Regulation of key proteins by microRNAs (miRNAs) is an emergent field in biomedicine. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) is a relevant molecule for cardiovascular diseases, since it is the target of oral anticoagulant drugs and plays a role in soft tissue calcification. The o...

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Bibliographic Details
Published in:	Molecular medicine (Cambridge, Mass.) Vol. 18; no. 11; pp. 1466 - 1472
Main Authors:	Pérez-Andreu, Virginia, Teruel, Raúl, Corral, Javier, Roldán, Vanessa, García-Barberá, Nuria, Salloum-Asfar, Salam, Gómez-Lechón, María José, Bourgeois, Stephane, Deloukas, Panos, Wadelius, Mia, Vicente, Vicente, González-Conejero, Rocío, Martínez, Constantino
Format:	Journal Article
Language:	English
Published:	England BioMed Central 2012 ScholarOne
Subjects:	3' Untranslated Regions - genetics Antibiotics Anticoagulants Base Sequence Binding sites Binding Sites - genetics Cloning Computational Biology Drug dosages Gene expression Gene Expression Regulation Genes, Reporter HEK293 Cells Hep G2 Cells Humans Liver - metabolism Liver cancer MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Molecular Sequence Data Mutagenesis Plasmids Proteins Reproducibility of Results RNA, Messenger - genetics RNA, Messenger - metabolism Thermodynamics Vitamin K - metabolism Vitamin K Epoxide Reductases United States > US
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