Insulin-derived amyloidosis

• Published in: Indian journal of endocrinology and metabolism Vol. 19; no. 1; pp. 174 - 177
• Main Authors: Gupta, Yashdeep, Singla, Gaurav, Singla, Rajiv
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01-01-2015; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Amyloidosis; Brief Communication; Complications and side effects; Diabetes; Diagnosis; Insulin; insulin injection; insulin resistance; localized amyloidosis; Risk factors; India; insulin injection; Diabetes; insulin; insulin resistance; localized amyloidosis
• ISSN: 2230-8210; 2230-9500
• DOI: 10.4103/2230-8210.146879

Amyloidosis is the term for diseases caused by the extracellular deposition of insoluble polymeric protein fibrils in tissues and organs. Insulin-derived amyloidosis is a rare, yet significant complication of insulin therapy. Insulin-derived amyloidosis at injection site can cause poor glycemic control and increased insulin dose requirements because of the impairment in insulin absorption, which reverse on change of injection site and/or excision of the mass. This entity should be considered and assessed by histopathology and immunohistochemistry, in patients with firm/hard local site reactions, which do not regress after cessation of insulin injection at the affected site.
PubMed was searched with terms "insulin amyloidosis". Full text of articles available in English was reviewed. Relevant cross references were also reviewed. Last search was made on October 15, 2014.