Detection of EGFR, KRAS and BRAF mutations in metastatic cells from cerebrospinal fluid

In lung adenocarcinoma, molecular profiling of actionable genes has become essential to set up targeted therapies. However, the feasibility and the relevance of molecular profiling from the cerebrospinal fluid (CSF) in the context of meningeal metastasis have been poorly assessed. We selected patien...

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Bibliographic Details
Published in:	Clinical chemistry and laboratory medicine Vol. 56; no. 5; p. 851
Main Authors:	Frankel, Diane, Nanni-Metellus, Isabelle, Robaglia-Schlupp, Andrée, Tomasini, Pascale, Guinde, Julien, Barlesi, Fabrice, Astoul, Philippe, Ouafik, L'Houcine, Amatore, Florent, Secq, Véronique, Kaspi, Elise, Roll, Patrice
Format:	Journal Article
Language:	English
Published:	Germany 25-04-2018
Subjects:	Adenocarcinoma of Lung - cerebrospinal fluid Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology Aged ErbB Receptors - chemistry ErbB Receptors - genetics Female Humans Lung Neoplasms - cerebrospinal fluid Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Mutation Proto-Oncogene Proteins B-raf - chemistry Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - chemistry Proto-Oncogene Proteins p21(ras) - genetics meningeal metastasis BRAF KRAS EGFR cerebrospinal fluid lung adenocarcinoma
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