Antisense oligodeoxynucleotide targeting HER2 mRNA sensitized docetaxel in breast cancer treatment

Human epidermal growth factor receptor 2 (HER2) is one of the oncogenes closely associated with the development and prognosis of breast carcinoma. Down-regulation of HER2 mRNA by antisense oligodeoxynucleotide (ASO) HER2 has been suggested to be a feasible treatment for patients with breast carcinom...

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Bibliographic Details
Published in:	Pharmaceutical biology Vol. 49; no. 11; p. 1167
Main Authors:	Sun, Junzhong, Xu, Yin, Song, Santai, Wu, Zuze, Duan, Haifeng
Format:	Journal Article
Language:	English
Published:	England 01-11-2011
Subjects:	Animals Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Down-Regulation Female Genetic Therapy - methods Humans Inhibitory Concentration 50 Mice Mice, Inbred BALB C Mice, Nude Oligodeoxyribonucleotides, Antisense - metabolism Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Taxoids - pharmacology Time Factors Transfection Tumor Burden - drug effects Xenograft Model Antitumor Assays
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