Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s disease

• Published in: Clinical neurophysiology Vol. 127; no. 1; pp. 537 - 543
• Main Authors: Christensen, Julie Anja Engelhard, Jennum, Poul, Koch, Henriette, Frandsen, Rune, Zoetmulder, Marielle, Arvastson, Lars, Christensen, Søren Rahn, Sorensen, Helge Bjarrup Dissing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-01-2016
• Subjects: Aged; Data-driven detection; Female; Humans; Male; Middle Aged; Neurology; Parkinson Disease - diagnosis; Parkinson Disease - epidemiology; Parkinson Disease - physiopathology; Parkinson’s disease; Polysomnography; Polysomnography - methods; Rapid eye movement sleep behavior disorder; REM Sleep Behavior Disorder - diagnosis; REM Sleep Behavior Disorder - epidemiology; REM Sleep Behavior Disorder - physiopathology; Sleep Stages - physiology; Sleep transitions; DCSM; Sublaterodorsal tegmental nucleus; NREM; MSLT; SLD; Rapid eye movement sleep; RBD; W; American Academy of Sleep Medicine; EOG; electrooculography; SS; Data-driven detection; AASM; Non-rapid eye movement sleep; Multiple sleep latency test; Periodic leg movement disorder; PSG; Idiopathic rapid eye movement sleep behavior disorder; Polysomnography; Danish Center for Sleep Medicine; RSWA; Wake; Sleep transitions; PD; Rapid eye movement sleep behavior disorder; REM sleep without atonia; PLMD; iRBD; REM; Sleep spindles; Parkinson’s disease
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2015.03.006

Highlights • Wake and sleep stability is affected in early stages of Parkinson’s disease. • An automated REM stability index is a potential biomarker for Parkinson’s disease. • We discuss problems linked to micro-sleep and nocturnal sleep fragmentation.