STING, DCs and the link between innate and adaptive tumor immunity

•Dendritic cells (DCs) serve as the cellular link between innate and adaptive anti-tumor immunity.•DCs are essential for cross-priming adaptive T cell responses against tumors.•STING-mediated Type I IFN induction in DCs is essential for spontaneous and therapy induced anti-tumor T cell responses.•DN...

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Bibliographic Details
Published in:	Molecular immunology Vol. 110; pp. 13 - 23
Main Authors:	Vatner, Ralph E., Janssen, Edith M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2019
Subjects:	Adaptive Immunity - physiology Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - physiology Cancer immunotherapy Dendritic cell Dendritic Cells - physiology Humans Immunity, Innate - physiology Interferon Interferons - genetics Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Radiation therapy Signal Transduction - physiology STING Tumor Escape - genetics Tumor Escape - immunology Tumor immunity Dendritic cell STING Interferon Tumor immunity Radiation therapy Cancer immunotherapy
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