Elemental Enteral Nutrition Preserves the Mucosal Barrier and Improves the Trophism of the Villi After Small Bowel Transplantation in Piglets

• Published in: Transplantation proceedings Vol. 39; no. 6; pp. 2024 - 2027
• Main Authors: Zonta, S, Doni, M, Alessiani, M, Lovisetto, F, Vigano, J, Mazzilli, M, Dominioni, T, Podetta, M, De Martino, M, Scaglione, M, Vicini, E, Bottazzi, A, Villa, C, Morbini, P, Dionigi, P
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01-07-2007; Elsevier Science
• Subjects: Animal Nutritional Physiological Phenomena; Animals; Biological and medical sciences; Enteral Nutrition; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Intestinal Absorption; Intestinal Mucosa - physiology; Intestine, Small - transplantation; Medical sciences; Microvilli - physiology; Models, Animal; Pneumonia; Postoperative Complications - classification; Sepsis; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Swine; Tissue, organ and graft immunology; Transplantation, Homologous; Xylose; Accessibility; Digestive system; Mucosa; Barrier; Transplantation; Homotransplantation; Small intestine; Young animal; Care; Enteral administration; Feeding; Pig; Medicine; Vertebrata; Improvement; Mammalia; Treatment; Surgery; Newborn animal; Graft; Artiodactyla; Villi; Ungulata
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2007.05.048

Abstract The main goals for a successful small bowel transplantation (SBTx) are the control of acute rejection and maintenance of the mucosal barrier, which plays a key role in preventing bacterial translocation and preserving absorptive capacity. According to recent evidence that sustaining enteral nutrition (EN) as rehabilitative therapy improves the integrity of the mucosal barrier after SBTx, we studied the trophic effect of a new elemental enteral solution whose proteinic supply is represented by oligomeric-aminoacidic chains. In a swine SBTx model we studied three groups, divided by the different postoperative feeding: group 1 ( n = 5): standard swine chow, group 2 ( n = 5): polymeric enteral solution, group 3 ( n = 5): elemental enteral solution (Peptamen, Nestlè Corp). All animals were immunosuppressed with a tacrolimus/FK778 combined oral therapy. The nutritional indices evaluated were: body weight, episodes of diarrhea, D-xylose absorption test, and histopatological and villi morphometric analysis. Three pigs died before the end of the study, two in group 1 (pneumonia and sepsis), one in group 2 (pneumonia). Mean days of diarrhea were 15, 10, and 3 in groups 1, 2, and 3, respectively ( P < .05). The final/starting weight ratio was 1.08 for group 3 and 0.92 for group 2 ( P < .05); the D-xylose curves showed a statistically significant difference for group 3 versus the groups 2 and 1 ( P < .05), as well as for the villi height ( P < .01) and width ( P < .05). In conclusion, elemental enteral solution, with its basic protein supply, does not require a very complex enzymatic system to be metabolized. Thus, it may contribute to a faster recovery of the mucosal barrier and to limit the hypercatabolic state.