Data resource profile: COVid VAXines effects on the aged (COVVAXAGE)
To improve the assessment of COVID-19 vaccine use, safety, and effectiveness in older adults and persons with complex multimorbidity, the COVid VAXines Effects on the Aged (COVVAXAGE) database was established by linking CVS Health and Walgreens pharmacy customers to Medicare claims. We deterministic...
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| Published in: | International journal of population data science Vol. 8; no. 6; p. 2170 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Wales
Swansea University
01-01-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | To improve the assessment of COVID-19 vaccine use, safety, and effectiveness in older adults and persons with complex multimorbidity, the COVid VAXines Effects on the Aged (COVVAXAGE) database was established by linking CVS Health and Walgreens pharmacy customers to Medicare claims.
We deterministically linked CVS Health and Walgreens customers who had a pharmacy dispensation/encounter paid for by Medicare to Medicare enrollment and claims records. Linked data include U.S. Medicare claims, Medicare enrollment files, and community pharmacy records. The data currently span 01/01/2016 to 08/31/2022. "Research-ready" files were created, with weekly indicators for vaccinations, censoring, death, enrollment, demographics, and comorbidities. Data are updated quarterly.
As of November 2022, records for 27,086,723 CVS Health and 23,510,025 Walgreens unique customer IDs were identified for potential linkage. Approximately 91% of customers were matched to a Medicare beneficiary ID (95% for those aged 65 years or older). In the final linked cohort, there were 38,250,873 unique beneficiaries representing ~60% of the Medicare population. Among those alive and enrolled in Medicare as of January 1, 2020 (n = 33,721,568; average age = 73 years, 74% White, 51% Medicare Fee-for-Service, and 11% dual-eligible for Medicaid), the average follow-up time was 130 weeks. The cohort contains 16,021,055 beneficiaries with evidence a first COVID-19 vaccine dose. Data are stored on the secure Medicare & Medicaid Resource Information Center Health & Aging Data Enclave.
Investigators with funded or in-progress funding applications to the National Institute on Aging who are interested in learning more about the database should contact Dr Vincent Mor [Vincent_mor@brown.edu] and Dr Kaleen Hayes [kaley_hayes@brown.edu]. A data dictionary can be provided under reasonable request.
The COVVAXAGE cohort is a large and diverse cohort that can be used for the ongoing evaluation of COVID-19 vaccine use and other research questions relevant to the Medicare population. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conflict of interest: Kaleen Hayes has received grant funding paid directly to Brown University for collaborative research from Insight Therapeutics and Sanofi Pasteur for research on complex insulin regimens. Kaleen Hayes also serves as a consultant for the Canadian Agency for Drugs and Technologies in Health. Andrew Zullo has received grant funding paid directly to Brown University by Sanofi for collaborative research on the epidemiology of infections and vaccinations among nursing home residents and infants. Stefan Gravenstein is a recipient of support from the U.S. Department of Veterans Affairs and investigator-initiated grants to Brown University and Lifespan from the National Institute of Allergy and Infectious Diseases (NIAID) to study influenza vaccine and COVID-19 in the nursing home, Pfizer to study pneumococcal vaccines, and from Sanofi Pasteur and Seqirus to study influenza vaccines. Stefan Gravenstein also performs consulting work for Icosavax, Janssen, Merck, Moderna, Novavax, Pfizer, Sanofi, Seqirus, and Vaxart; has served on the speaker’s bureaus for Seqirus, Janssen and Sanofi; and was paid to chair data safety monitoring boards from Longeveron and SciClone. Acumen, LLC (Sean McCurdy, Kristina Baird, Daniel Moran, Derek Fenson) has received federal funding from the National Institutes of Health, the Centers for Medicare & Medicaid Services, and the U.S. Food and Drug Administration to study vaccine safety and to provide vaccination surveillance support. Renae Smith-Ray, Michael Taitel, and Tanya Singh are employees of Walgreens and have received funding from Moderna and Pfizer to study vaccine uptake and effectiveness. Djeneba Audrey Djibo and Cheryl McMahill-Walraven are full-time employees of CVS Health and conduct work for government, public, and private organizations, including pharmaceutical companies, as part of their employment. All other authors have no COI to report. |
| ISSN: | 2399-4908 2399-4908 |
| DOI: | 10.23889/ijpds.v8i6.2170 |