Cell surface proteoglycan of mammary epithelial cells. Protease releases a heparan sulfate-rich ectodomain from a putative membrane-anchored domain

Heparan sulfate-rich proteoglycan is present on the surface of NMuMG mouse mammary epithelial cells. All of this cell surface fraction is lipophilic, assessed by intercalation into lipid vesicles, and requires proteolytic cleavage to be released from the cell surface. No proteoglycan is competitivel...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 260; no. 7; pp. 4103 - 4109
Main Authors:	Rapraeger, A, Bernfield, M
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Elsevier Inc 10-04-1985 American Society for Biochemistry and Molecular Biology
Subjects:	Animals Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Centrifugation, Density Gradient Chondroitin Sulfate Proteoglycans - analysis Chromatography, Gel Epithelium - analysis Female Fundamental and applied biological sciences. Psychology Glycosaminoglycans - analysis Heparan Sulfate Proteoglycans Heparin - metabolism Heparitin Sulfate - analysis Mammary Glands, Animal - cytology Mice Molecular and cellular biology Peptide Hydrolases - metabolism Proteoglycans - analysis Sulfates - metabolism Proteoglycan Cell culture Membrane protein Proteinase Rodentia Glycoproteins Cell surface Vertebrata Mammalia Mouse Epithelial cell Mammary gland Molecular accessibility
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