Pattern-Reversal Visual Evoked Potentials in Patients With Epiretinal Membrane

• Published in: American journal of ophthalmology Vol. 123; no. 1; pp. 97 - 102
• Main Authors: BEMELMANS, NICOLE A.M., TILANUS, MAURITS A.D., CUYPERS, MARINUS H.M., PINCKERS, ALFRED J.L.G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-01-1997; Elsevier; Elsevier Limited
• Subjects: Biological and medical sciences; Evoked Potentials, Visual; Humans; Medical sciences; Membranes - physiology; Middle Aged; Ophthalmology; Photic Stimulation - methods; Reaction Time; Retina - physiology; Retinopathies; Visual Acuity; Human; Electrodiagnosis; Macula; Eye disease; Retinopathy; Epiretinal membrane; Exploration; Visual evoked potential pattern
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/S0002-9394(14)70998-5

To determine the extent of pattern-reversal visual evoked potential parameter alteration by epiretinal membranes and to investigate the use of pattern-reversal visual evoked potential in the estimation of macular function in eyes with epiretinal membrane and in the fellow eyes.
In both eyes of 162 patients with epiretinal membrane, 92 of primary and 70 of secondary origin, pattern-reversal visual evoked potentials were recorded. Check sizes of 17', 10', and 7' (minutes of arc) were used. Parameters investigated were N80 and P100 latencies and P100 amplitude.
No significant difference was detected between eyes with epiretinal membrane of primary and secondary origin regarding visual acuity and the pattern-reversal visual evoked potential parameters for the different check sizes. Compared with the fellow eyes, the eyes with epiretinal membrane had a significantly reduced visual acuity, prolonged N80 and P100 latencies, and a reduced P100 amplitude for the different check sizes. Compared with a separate control group (N = 20) with patients 50 to 59 years old, eyes with epiretinal membrane (N = 9) showed the same features as in the total group, but only for the 17' and 10' check sizes. The fellow eyes (N = 9) showed a significant reduction of the P100 amplitude (P < .05) for the pattern sizes of 17' and 10', but no difference in visual acuity or pattern-reversal visual evoked potential latency was found.
In eyes with epiretinal membrane, pattern-reversal visual evoked potential latencies are prolonged, and amplitude is reduced. Relationships between clinical parameters and pattern-reversal visual evoked potential parameters require further study.