Anthelmintic effect of Eucalyptus staigeriana essential oil against goat gastrointestinal nematodes

• Published in: Veterinary parasitology Vol. 173; no. 1; pp. 93 - 98
• Main Authors: Macedo, Iara T.F., Bevilaqua, Claudia M.L., de Oliveira, Lorena M.B., Camurça-Vasconcelos, Ana L.F., Vieira, Luiz da S., Oliveira, Fabrício R., Queiroz-Junior, Eudson M., Tomé, Adriana da R., Nascimento, Nilberto R.F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 11-10-2010; Amsterdam; New York: Elsevier
• Subjects: Animals; Anthelmintic; anthelmintics; Anthelmintics - chemistry; Anthelmintics - pharmacology; drug therapy; essential oils; Eucalyptus; Eucalyptus - chemistry; Eucalyptus staigeriana; fecal egg count; Feces - parasitology; Female; gastrointestinal nematodes; goat diseases; Goat Diseases - drug therapy; Goat Diseases - parasitology; Goats; Haemonchus - drug effects; Haemonchus contortus; hatching; histopathology; In vitro; in vitro studies; In vivo; in vivo studies; inhibitors; Larva - drug effects; larval development; Male; medicinal properties; Mice; Nematoda; nematode infections; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; ova; Ovum - drug effects; Parasite Egg Count - veterinary; phytochemicals; Phytotherapy; Rats; Rats, Wistar; Toxicity; toxicity testing; In vivo; Anthelmintic; Phytotherapy; Toxicity; In vitro
• ISSN: 0304-4017; 1873-2550
• DOI: 10.1016/j.vetpar.2010.06.004

The aim of this study was to evaluate the anthelmintic efficacy of
Eucalyptus staigeriana essential oil (EsEO). The
in vitro effects of EsEO were determined through the egg hatching test and the inhibition of larval development of
Haemonchus contortus. The oil was subjected to acute and subacute toxicity rodents. The
in vivo effects were determined through fecal egg count reduction test in goats. 1.35 and 5.4
mg
ml
−1 EsEO inhibited 99.27 and 99.20%
H. contortus egg hatching and larval development. In subacute toxicity of EsEO, all parameters were found to be in the normal range, and histopathological analysis of organs did not present alterations. EsEO efficacy against goat gastrointestinal nematodes was 76.57% at 15th day after treatment.
E. staigeriana essential oil showed
in vitro and
in vivo anthelmintic activity.