Effect of periodontal therapy on metabolic control and levels of IL-6 in the gingival crevicular fluid in type 2 diabetes mellitus

• Published in: Indian journal of dental research Vol. 24; no. 1; pp. 110 - 116
• Main Authors: Galhardo Camargo, Gabriela, de Andrade Lima, Meyriane, Fortes, Tânia, de Souza, Cristiane, de Jesus, Amélia, de Almeida, Roque
• Format: Journal Article
• Language: English
• Published: Mangalore Medknow Publications 01-01-2013; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Apoptosis; Care and treatment; Cytokines; Diabetes; Diabetes therapy; Disease; Fluids; interleukin; Interleukins; Metabolites; Nutrition research; Oral hygiene; Patients; periodontal disease; Sample size; Standard deviation; Statistical analysis; Studies; Teeth; Type 2 diabetes; interleukin; periodontal disease; Diabetes
• ISSN: 0970-9290; 1998-3603
• DOI: 10.4103/0970-9290.114953

Background: The aim of this study was to compare the efficacy of metabolic control and levels of interleukin 6 (IL-6) in gingival crevicular fluid after periodontal therapy in type 2 diabetes mellitus (DM) and nondiabetic (NDM) patients.
Methods: This study was performed in 20 subjects (10 type 2 DM and 10 NDM patients with generalized chronic periodontal disease. Both groups were recorded for clinical parameters (plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR) and clinical attachment level (CAL)), metabolic control (fasting glucose levels, glycated a-hemoglobin (HbA1c), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TR)), and IL-6 levels at baseline and 3 months after periodontal treatment.
Results: DM and NDM patients revealed significant statistical reductions for clinical parameters (P < 0.05, RM ANOVA) after 3 months. DM group had improvements on HbA1c and had significant statistical increased of TRG (P < 0.05, RM ANOVA) after 3 months. No differences of LDL/HDL and IL-6 levels were found after 3 months in both groups.
Conclusion: DM group presented a significant reduction of HbA1c levels after periodontal therapy. However, TRG levels increased after 3 months, which suggest more confirmatory studies to investigate if these results will be repeated in other studies.