The ACTN3 R577X Polymorphism Is Associated With Muscle Power in Male Japanese Athletes

• Published in: Journal of strength and conditioning research Vol. 28; no. 7; pp. 1783 - 1789
• Main Authors: Kikuchi, Naoki, Nakazato, Koichi, Min, Seok-ki, Ueda, Dai, Igawa, Shoji
• Format: Journal Article
• Language: English
• Published: United States Copyright by the National Strength & Conditioning Association 01-07-2014; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Actinin - genetics; Adolescent; Asian Continental Ancestry Group - genetics; Athletes; Athletic Performance - physiology; College sports; Exercise Test; Female; Genotype; Genotype & phenotype; Humans; Japan; Male; Muscle Strength - genetics; Muscle, Skeletal - physiology; Muscular system; Polymorphism; Polymorphism, Genetic; Sex Factors; Young Adult; Japan
• ISSN: 1064-8011; 1533-4287
• DOI: 10.1519/JSC.0000000000000338

ABSTRACTKikuchi, N, Nakazato, K, Min, S-k, Ueda, D, and Igawa, S. The ACTN3 R577X polymorphism is associated with muscle power in male Japanese athletes. J Strength Cond Res 28(7)1783–1789, 2014—In this study, we investigated whether the ACTN3 R577X polymorphism is associated with muscular power in Japanese collegiate athletes by analyzing the mean and peak power results of a 30-second Wingate anaerobic test (WAnT) with respect to the ACTN3 R577X genotype in 253 Japanese athletes (144 men and 109 women). Each athlete performed a 30-second WAnT with a resistance equal to 7.5% of his or her body weight. Genotyping for the ACTN3 R577X (rs1815739) polymorphism was performed using the TaqMan approach. The ACTN3 R577X genotypes exhibited a Hardy-Weinberg equilibrium distribution in our population. The relative and absolute mean power results of the 30-second WAnT did not differ significantly among the genotypes. However, the relative peak power result of the WAnT was significantly higher in the R-allele-dominant model groups than in the XX group in male but not female athletes. These results suggest that the ACTN3 R allele is associated with the relative peak power during the WAnT in male Japanese collegiate athletes.