Neuronal calcium sensor‐1 facilitates neuronal exocytosis through phosphatidylinositol 4‐kinase

This work tested the theory that neuronal calcium sensor‐1 (NCS‐1) has effects on neurotransmitter release beyond its actions on membrane channels. We used nerve‐ending preparations where membrane channels are bypassed through membrane permeabilization made by mechanical disruption or streptolysin‐O...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 92; no. 3; pp. 442 - 451
Main Authors:	Zheng, Qian, Bobich, Joseph A., Vidugiriene, Jolanta, McFadden, Susanne C., Thomas, Fairwell, Roder, John, Jeromin, Andreas
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-02-2005 Blackwell
Subjects:	1-Phosphatidylinositol 4-Kinase - chemistry 1-Phosphatidylinositol 4-Kinase - drug effects 1-Phosphatidylinositol 4-Kinase - metabolism Animals Antibodies - pharmacology Biological and medical sciences Calcium - chemistry Calcium - metabolism Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - pharmacology Calcium-Binding Proteins - physiology Cell physiology Cerebral Cortex - chemistry Dose-Response Relationship, Drug Exocytosis - drug effects Exocytosis - physiology Female Fundamental and applied biological sciences. Psychology glutamate Male Molecular and cellular biology Nerve Endings - chemistry Nerve Endings - drug effects Nerve Endings - metabolism Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - pharmacology Nerve Tissue Proteins - physiology neuronal calcium sensor‐1 Neuronal Calcium-Sensor Proteins Neurons - chemistry Neuropeptides Neurotransmitter Agents - chemistry Neurotransmitter Agents - metabolism neurotransmitter release norepinephrine Peptide Fragments - pharmacology Phosphatidylinositol 4,5-Diphosphate - biosynthesis Phosphatidylinositol 4,5-Diphosphate - chemistry phosphatidylinositol 4‐kinase Phosphatidylinositol Phosphates - biosynthesis Phosphatidylinositol Phosphates - chemistry Rats Rats, Sprague-Dawley Rats, Wistar Secretion. Exocytosis Subcellular Fractions - chemistry Subcellular Fractions - metabolism norepinephrine Calcium Enzyme Transferases Catecholamine Exocytosis neurotransmitter release 1-Phosphatidylinositol 4-kinase Phosphatidylinositol Nerve ending neuronal calcium sensor-1 Excitatory aminoacid Neurotransmitter Membrane channel Release glutamate phosphatidylinositol 4-kinase
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