Effect of White Light Devoid of “Cyan” Spectrum Radiation on Nighttime Melatonin Suppression Over a 1-h Exposure Duration

• Published in: Journal of biological rhythms Vol. 34; no. 2; pp. 195 - 204
• Main Authors: Nagare, Rohan, Rea, Mark S., Plitnick, Barbara, Figueiro, Mariana G.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-04-2019; SAGE PUBLICATIONS, INC
• Subjects: Adult; Biological Clocks; Circadian Rhythm - radiation effects; Circadian rhythms; Darkness; Design of experiments; Diodes; Experimental design; Exposure; Eye; Eye (anatomy); Eye - radiation effects; Female; Humans; Hypothalamus; Illuminance; Light; Light levels; Light sources; Male; Melanopsin; Melatonin; Melatonin - radiation effects; Middle Aged; Photosensitivity; Radiation; Retina; Retinal ganglion cells; Saliva - chemistry; Spectrum Analysis; Time Factors; Wavelengths; White light; light at night; melatonin suppression; circadian; cyan-deficient lighting; cyan-gap lighting; spectrum
• ISSN: 0748-7304; 1552-4531
• DOI: 10.1177/0748730419830013

The intrinsically photosensitive retinal ganglion cells are the main conduit of the light signal emanating from the retina to the biological clock located in the suprachiasmatic nuclei of the hypothalamus. Lighting manufacturers are developing white light sources that are devoid of wavelengths around 480 nm (“cyan gap”) to reduce their impact on the circadian system. The present study was designed to investigate whether exposure to a “cyan-gap,” 3000 K white light source, spectrally tuned to reduce radiant power between 475 and 495 nm (reducing stimulation of the melanopsin-containing photoreceptor), would suppress melatonin less than a conventional 3000 K light source. The study’s 2 phases employed a within-subjects experimental design involving the same 16 adult participants. In Phase 1, participants were exposed for 1 h to 3 experimental conditions over the course of 3 consecutive weeks: 1) dim light control (<5 lux at the eyes); 2) 800 lux at the eyes of a 3000 K light source; and 3) 800 lux at the eyes of a 3000 K, “cyan-gap” modified (3000 K mod) light source. The same protocol was repeated in Phase 2, but light levels were reduced to 400 lux at the eyes. As hypothesized, there were significant main effects of light level (F1,12 = 9.1, p < 0.05, ηp² = 0.43) and exposure duration (F1,12 = 47.7, p < 0.05, ηp² = 0.80) but there was no significant main effect of spectrum (F1,12 = 0.16, p > 0.05, ηp² = 0.01). There were no significant interactions with spectrum. Contrary to our model predictions, our results showed that short-term exposures (≤ 1 h) to “cyan-gap” light sources suppressed melatonin similarly to conventional light sources of the same CCT and photopic illuminance at the eyes.