Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients

Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia wa...

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Published in:	Journal of neuroimmunology Vol. 313; pp. 82 - 88
Main Authors:	Leal, Bárbara, Chaves, João, Carvalho, Cláudia, Rangel, Rui, Santos, Agostinho, Bettencourt, Andreia, Lopes, João, Ramalheira, João, Silva, Berta M., da Silva, António Martins, Costa, Paulo P.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-12-2017
Subjects:	Activated microglia Adult Brain - metabolism Cytokines Cytokines - metabolism Epilepsy Epilepsy, Temporal Lobe - immunology Epilepsy, Temporal Lobe - pathology Female Hippocampus HLA-DR Antigens - metabolism Humans Inflammation Male Microglia - metabolism Microglia - pathology Middle Aged Toll-Like Receptor 4 - metabolism Young Adult AMPA Cytokines Epilepsy Inflammation HMGB1 FS TNF Activated microglia ASD TGF GABA NMDA TLR HLA ATP MTLE-HS Hippocampus PET DAMP
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Abstract	Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+ microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex. •Activated microglia is present in hippocampus and anterior cortex of MTLE-HS.•IL-1β and TLR4 are upregulated in hippocampus and cortex of MTLE-HS patients.•Cortical and hippocampal upregulation of anti-inflammatory cytokine IL-10 was observed in MTLE-HS patients.•Inflammatory response associated with seizure propagation.
AbstractList	Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+ microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex. Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex. Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+ microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex. •Activated microglia is present in hippocampus and anterior cortex of MTLE-HS.•IL-1β and TLR4 are upregulated in hippocampus and cortex of MTLE-HS patients.•Cortical and hippocampal upregulation of anti-inflammatory cytokine IL-10 was observed in MTLE-HS patients.•Inflammatory response associated with seizure propagation.
Author	da Silva, António Martins Rangel, Rui Costa, Paulo P. Leal, Bárbara Ramalheira, João Carvalho, Cláudia Chaves, João Bettencourt, Andreia Silva, Berta M. Lopes, João Santos, Agostinho
Author_xml	– sequence: 1 givenname: Bárbara surname: Leal fullname: Leal, Bárbara email: baleal@icbas.up.pt organization: UMIB – Instituto de Ciências Biomédicas Abel Salazar [ICBAS], Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal – sequence: 2 givenname: João surname: Chaves fullname: Chaves, João organization: Serviço de Neurologia, Hospital de Santo António, Centro Hospitalar e Universitário do Porto, Largo Prof. Abel Salazar, 4099-003 Porto, Portugal – sequence: 3 givenname: Cláudia surname: Carvalho fullname: Carvalho, Cláudia organization: UMIB – Instituto de Ciências Biomédicas Abel Salazar [ICBAS], Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal – sequence: 4 givenname: Rui surname: Rangel fullname: Rangel, Rui organization: Serviço de Neurocirurgia, Hospital de Santo António, Centro Hospitalar e Universitário do Porto, Largo Prof. Abel Salazar, 4099-003 Porto, Portugal – sequence: 5 givenname: Agostinho surname: Santos fullname: Santos, Agostinho organization: Serviço de Patologia Forense, Instituto Nacional de Medicina Legal e ciências Forenses – Delegação do Norte (INMLCF-DN), Porto, Portugal – sequence: 6 givenname: Andreia surname: Bettencourt fullname: Bettencourt, Andreia organization: UMIB – Instituto de Ciências Biomédicas Abel Salazar [ICBAS], Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal – sequence: 7 givenname: João surname: Lopes fullname: Lopes, João organization: Serviço de Neurofisiologia, Hospital de Santo António, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-003 Porto, Portugal – sequence: 8 givenname: João surname: Ramalheira fullname: Ramalheira, João organization: Serviço de Neurofisiologia, Hospital de Santo António, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-003 Porto, Portugal – sequence: 9 givenname: Berta M. surname: Silva fullname: Silva, Berta M. organization: UMIB – Instituto de Ciências Biomédicas Abel Salazar [ICBAS], Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal – sequence: 10 givenname: António Martins surname: da Silva fullname: da Silva, António Martins organization: UMIB – Instituto de Ciências Biomédicas Abel Salazar [ICBAS], Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal – sequence: 11 givenname: Paulo P. surname: Costa fullname: Costa, Paulo P. organization: UMIB – Instituto de Ciências Biomédicas Abel Salazar [ICBAS], Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29153613$$D View this record in MEDLINE/PubMed
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Keywords	AMPA Cytokines Epilepsy Inflammation HMGB1 FS TNF Activated microglia ASD TGF GABA NMDA TLR HLA ATP MTLE-HS Hippocampus PET DAMP
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Snippet	Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy...
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SubjectTerms	Activated microglia Adult Brain - metabolism Cytokines Cytokines - metabolism Epilepsy Epilepsy, Temporal Lobe - immunology Epilepsy, Temporal Lobe - pathology Female Hippocampus HLA-DR Antigens - metabolism Humans Inflammation Male Microglia - metabolism Microglia - pathology Middle Aged Toll-Like Receptor 4 - metabolism Young Adult
Title	Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients
URI	https://dx.doi.org/10.1016/j.jneuroim.2017.10.014 https://www.ncbi.nlm.nih.gov/pubmed/29153613 https://search.proquest.com/docview/1966448501
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