Deubiquitinase Inhibitor b-AP15 Attenuated LPS-Induced Inflammation via Inhibiting ERK1/2, JNK, and NF-Kappa B

b-AP15 is a deubiquitinase (DUB) inhibitor of 19S proteasomes, which in turn targets ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14). Nuclear factor kappa B (NF-κB) is closely linked to cellular response in macrophages when the organism is in the state of microbi...

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Published in:	Frontiers in molecular biosciences Vol. 7; p. 49
Main Authors:	Zhang, Fangcheng, Xu, Ruqin, Chai, Renjie, Xu, Qiong, Liu, Mingke, Chen, Xuke, Chen, Xiaohua, Kong, Tianyu, Zhang, Chongyu, Liu, Shi-Ming, Zhang, Zhenhui, Liu, Ningning
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 22-04-2020
Subjects:	b-AP15 deubiquitinase inhibitor ERK1/2 inflammation JNK Molecular Biosciences NF-κB NF-κB ERK1/2 deubiquitinase inhibitor inflammation b-AP15 JNK
Online Access:	Get full text
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