Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely...
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| Published in: | Frontiers in immunology Vol. 8; p. 1078 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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04-09-2017
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| Abstract | Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely correlated with telomere length in a range of major pathologies. The current review discusses the impact of inflammation on immune aging, the likely molecular mediators of this process, and the various disease states that have been linked with immunosenescence. Emerging findings implicate NF-κB, the major driver of inflammatory signaling, in several processes that regulate telomere maintenance and/or telomerase activity. While prolonged triggering of pattern recognition receptors is now known to promote immunosenescence, it remains unclear how this process is linked with the telomere complex or telomerase activity. Indeed, enzymatic control of telomere length has been studied for many decades, but alternative roles of telomerase and potential influences on inflammatory responses are only now beginning to emerge. Crosstalk between these pathways may prove to be a key molecular mechanism of immunosenescence. Understanding how components of immune aging interact and modify host protection against pathogens and tumors will be essential for the design of new vaccines and therapies for a wide range of clinical scenarios. |
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| AbstractList | Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely correlated with telomere length in a range of major pathologies. The current review discusses the impact of inflammation on immune aging, the likely molecular mediators of this process, and the various disease states that have been linked with immunosenescence. Emerging findings implicate NF-κB, the major driver of inflammatory signaling, in several processes that regulate telomere maintenance and/or telomerase activity. While prolonged triggering of pattern recognition receptors is now known to promote immunosenescence, it remains unclear how this process is linked with the telomere complex or telomerase activity. Indeed, enzymatic control of telomere length has been studied for many decades, but alternative roles of telomerase and potential influences on inflammatory responses are only now beginning to emerge. Crosstalk between these pathways may prove to be a key molecular mechanism of immunosenescence. Understanding how components of immune aging interact and modify host protection against pathogens and tumors will be essential for the design of new vaccines and therapies for a wide range of clinical scenarios. |
| Author | Jose, Shyam Sushama Krenova, Zdenka Fric, Jan Bendickova, Kamila Kepak, Tomas |
| AuthorAffiliation | 3 Pediatric Oncology Translational Research (POTR), International Clinical Research Center (ICRC), St. Anne’s University Hospital Brno , Brno , Czechia 1 Cellular and Molecular Immunoregulation Group (CMI), Center for Translational Medicine (CTM), International Clinical Research Center (ICRC), St. Anne’s University Hospital Brno , Brno , Czechia 4 Pediatric Hematology and Oncology, University Hospital Brno , Brno , Czechia 2 Department of Biology, Faculty of Medicine , Masaryk University , Czechia |
| AuthorAffiliation_xml | – name: 3 Pediatric Oncology Translational Research (POTR), International Clinical Research Center (ICRC), St. Anne’s University Hospital Brno , Brno , Czechia – name: 4 Pediatric Hematology and Oncology, University Hospital Brno , Brno , Czechia – name: 1 Cellular and Molecular Immunoregulation Group (CMI), Center for Translational Medicine (CTM), International Clinical Research Center (ICRC), St. Anne’s University Hospital Brno , Brno , Czechia – name: 2 Department of Biology, Faculty of Medicine , Masaryk University , Czechia |
| Author_xml | – sequence: 1 givenname: Shyam Sushama surname: Jose fullname: Jose, Shyam Sushama organization: Department of Biology, Faculty of Medicine, Masaryk University, Czechia – sequence: 2 givenname: Kamila surname: Bendickova fullname: Bendickova, Kamila organization: Cellular and Molecular Immunoregulation Group (CMI), Center for Translational Medicine (CTM), International Clinical Research Center (ICRC), St. Anne's University Hospital Brno, Brno, Czechia – sequence: 3 givenname: Tomas surname: Kepak fullname: Kepak, Tomas organization: Pediatric Hematology and Oncology, University Hospital Brno, Brno, Czechia – sequence: 4 givenname: Zdenka surname: Krenova fullname: Krenova, Zdenka organization: Pediatric Hematology and Oncology, University Hospital Brno, Brno, Czechia – sequence: 5 givenname: Jan surname: Fric fullname: Fric, Jan organization: Cellular and Molecular Immunoregulation Group (CMI), Center for Translational Medicine (CTM), International Clinical Research Center (ICRC), St. Anne's University Hospital Brno, Brno, Czechia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28928745$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2017 Jose, Bendickova, Kepak, Krenova and Fric. 2017 Jose, Bendickova, Kepak, Krenova and Fric |
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| Keywords | pattern recognition receptor signaling telomere shortening NF-κB inflammaging toll-like receptor signaling myelopoiesis |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Title | Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex? |
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