Epigenetic Factors and Mitochondrial Biology in Yeast: A New Paradigm for the Study of Cancer Metabolism?

Epigenetic Factors and Mitochondrial Biology in Yeast: A New Paradigm for the Study of Cancer Metabolism?

Bidirectional cross-talk between nuclear and mitochondrial DNA is fundamental for cell homeostasis. Epigenetic mechanisms regulate the inter-organelle communication between nucleus and mitochondria. Recent research highlights not only the retrograde activation of nuclear gene transcription in case o...

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Bibliographic Details
Published in:Frontiers in pharmacology Vol. 9; p. 1349
Main Authors: Stoppacciaro, Antonella, Di Vito, Serena, Filetici, Patrizia
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 21-11-2018
Subjects:
cancer
epigenetic
mitochondria
Pharmacology
reprogramming
yeast
reprogramming
cancer
epigenetic
mitochondria
yeast
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Summary:Bidirectional cross-talk between nuclear and mitochondrial DNA is fundamental for cell homeostasis. Epigenetic mechanisms regulate the inter-organelle communication between nucleus and mitochondria. Recent research highlights not only the retrograde activation of nuclear gene transcription in case of mitochondria dysfunction, but also the role of post-translational modifications of mitochondrial proteins in respiratory metabolism. Here we discuss some aspects and novel findings in . In yeast, KAT-Gcn5 and DUB-Ubp8 have a role in respiration and are localized, as single proteins, into mitochondria. These findings, beside the canonical and widely known nuclear activity of SAGA complex in chromatin regulation, provide novel clues on promising aspects linking evolutionary conserved epigenetic factors to the re-programmed metabolism of cancer cells.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Edited by: Lina Ghibelli, Università degli Studi di Roma Tor Vergata, Italy
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
Reviewed by: Ignacio Bejarano, Universidad de Extremadura, Spain; Lucia Altucci, Università degli Studi della Campania “Luigi Vanvitelli”, Italy
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2018.01349