CXCL17 and ICAM2 Are Associated With a Potential Anti-Tumor Immune Response in Early Intraepithelial Stages of Human Pancreatic Carcinogenesis

Background & Aims Anti-tumor immunity changes over the course of tumor progression; it is not clear how or when the developing tumor overcomes immune surveillance. Intraductal papillary mucinous neoplasm (IPMN) is an intraepithelial precursor lesion of pancreatic cancer that progresses from aden...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 140; no. 1; pp. 310 - 321.e4
Main Authors:	Hiraoka, Nobuyoshi, Yamazaki–Itoh, Rie, Ino, Yoshinori, Mizuguchi, Yasunori, Yamada, Tesshi, Hirohashi, Setsuo, Kanai, Yae
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 2011
Subjects:	Abscess - immunology Abscess - pathology Abscess - surgery Adenocarcinoma, Mucinous - immunology Adenocarcinoma, Mucinous - pathology Adenocarcinoma, Mucinous - surgery Adenocarcinoma, Papillary - immunology Adenocarcinoma, Papillary - pathology Adult Aged Animals Antigens, CD - immunology Carcinoma in Situ - immunology Carcinoma in Situ - pathology Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - pathology Cell Adhesion Molecules - immunology Cell Transformation, Neoplastic - immunology Cell Transformation, Neoplastic - pathology Chemokine Chemokine CCL17 - immunology Danger Signal Dendritic Cells - immunology Female Gastroenterology and Hepatology Gene Expression Profiling Humans Immunologic Surveillance Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Male Mice Mice, Inbred BALB C Middle Aged Multistep Carcinogenesis Neoplasm Staging Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Pancreatic Pseudocyst - immunology Pancreatic Pseudocyst - pathology Pancreatitis, Chronic - immunology Pancreatitis, Chronic - pathology Precancerous Conditions - immunology Precancerous Conditions - pathology Premalignant Lesion Retrospective Studies T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - pathology intraductal papillary mucinous adenoma Premalignant Lesion LFA-1 CXCL17 ICAM2 IPMN intraductal papillary mucinous neoplasm Multistep Carcinogenesis intercellular adhesion molecule 2 Chemokine Danger Signal Langerhans cell DC-SIGN dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin chemokine (C-X-C motif) ligand 17 intraductal papillary mucinous carcinoma LC PanIN IPMA lymphocyte function-associated antigen 1 pancreatic intraepithelial neoplasm dendritic cell DC IPMC
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