Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells

We previously showed that S-adenosylmethionine-mediated hypermethylation of the PTEN promoter was important for the growth of tamoxifen-resistant MCF-7 (TAMR-MCF-7) cancer cells. Here, we found that the basal expression level of methionine adenosyltransferase 2A (MAT2A), a critical enzyme for the bi...

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Bibliographic Details
Published in:	Oncotarget Vol. 7; no. 12; pp. 13902 - 13916
Main Authors:	Phuong, Nguyen Thi Thuy, Kim, Sang Kyum, Im, Ji Hye, Yang, Jin Won, Choi, Min Chang, Lim, Sung Chul, Lee, Kwang Yeol, Kim, Young-Mi, Yoon, Jeong Hoon, Kang, Keon Wook
Format:	Journal Article
Language:	English
Published:	United States Impact Journals LLC 22-03-2016
Subjects:	Antineoplastic Agents, Hormonal - pharmacology Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Proliferation DNA Methylation Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic - drug effects Humans Methionine Adenosyltransferase - genetics Methionine Adenosyltransferase - metabolism MicroRNAs - genetics NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-kappa B - genetics NF-kappa B - metabolism Promoter Regions, Genetic PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Research Paper S-Adenosylmethionine - metabolism Signal Transduction Tamoxifen - pharmacology Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Tumor Cells, Cultured PTEN NF-κB miR-146b tamoxifen resistance MAT2A
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