Comparison of the clonality of urothelial carcinoma developing in the upper urinary tract and those developing in the bladder
Purpose To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the basic mechanism behind the multifocality of UC, which may provide a sound bases for the future development of new strategies for detect...
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| Abstract | Purpose
To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the basic mechanism behind the multifocality of UC, which may provide a sound bases for the future development of new strategies for detection, prevention and therapy.
Methods
Six patients with UC of the bladder and synchronous or metachronous UC of the upper urinary tract were studied. Genetic analysis involving the study of loss of heterozygosity (LOH) has been evaluated on their tumours using well characterised and new markers of UC (D9S171, D9S177, D9S303 and TP53).
Results
Five of the six patients demonstrated informative results. Four of five (80%) of patients had synchronous or metacharonous UC tumour and showed patterns of LOH consistent with tumorigenesis from monoclonal tumour origin. One of five (20%) patients exhibited a LOH consistent with oligoclonal tumorigenesis.
Conclusion
These findings suggest that both the monoclonal and field cancerization theory of tumorigenesis may play a role in tumors of the urothelial tract. However, more data is needed. |
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| AbstractList | Purpose To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the basic mechanism behind the multifocality of UC, which may provide a sound bases for the future development of new strategies for detection, prevention and therapy. Methods Six patients with UC of the bladder and synchronous or metachronous UC of the upper urinary tract were studied. Genetic analysis involving the study of loss of heterozygosity (LOH) has been evaluated on their tumours using well characterised and new markers of UC (D9S171, D9S177, D9S303 and TP53). Results Five of the six patients demonstrated informative results. Four of five (80%) of patients had synchronous or metacharonous UC tumour and showed patterns of LOH consistent with tumorigenesis from monoclonal tumour origin. One of five (20%) patients exhibited a LOH consistent with oligoclonal tumorigenesis. Conclusion These findings suggest that both the monoclonal and field cancerization theory of tumorigenesis may play a role in tumors of the urothelial tract. However, more data is needed. To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the basic mechanism behind the multifocality of UC, which may provide a sound bases for the future development of new strategies for detection, prevention and therapy. Six patients with UC of the bladder and synchronous or metachronous UC of the upper urinary tract were studied. Genetic analysis involving the study of loss of heterozygosity (LOH) has been evaluated on their tumours using well characterised and new markers of UC (D9S171, D9S177, D9S303 and TP53). Five of the six patients demonstrated informative results. Four of five (80%) of patients had synchronous or metacharonous UC tumour and showed patterns of LOH consistent with tumorigenesis from monoclonal tumour origin. One of five (20%) patients exhibited a LOH consistent with oligoclonal tumorigenesis. These findings suggest that both the monoclonal and field cancerization theory of tumorigenesis may play a role in tumors of the urothelial tract. However, more data is needed. PURPOSETo identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the basic mechanism behind the multifocality of UC, which may provide a sound bases for the future development of new strategies for detection, prevention and therapy. METHODSSix patients with UC of the bladder and synchronous or metachronous UC of the upper urinary tract were studied. Genetic analysis involving the study of loss of heterozygosity (LOH) has been evaluated on their tumours using well characterised and new markers of UC (D9S171, D9S177, D9S303 and TP53). RESULTSFive of the six patients demonstrated informative results. Four of five (80%) of patients had synchronous or metacharonous UC tumour and showed patterns of LOH consistent with tumorigenesis from monoclonal tumour origin. One of five (20%) patients exhibited a LOH consistent with oligoclonal tumorigenesis. CONCLUSIONThese findings suggest that both the monoclonal and field cancerization theory of tumorigenesis may play a role in tumors of the urothelial tract. However, more data is needed. Purpose To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the basic mechanism behind the multifocality of UC, which may provide a sound bases for the future development of new strategies for detection, prevention and therapy. Methods Six patients with UC of the bladder and synchronous or metachronous UC of the upper urinary tract were studied. Genetic analysis involving the study of loss of heterozygosity (LOH) has been evaluated on their tumours using well characterised and new markers of UC (D9S171, D9S177, D9S303 and TP53). Results Five of the six patients demonstrated informative results. Four of five (80%) of patients had synchronous or metacharonous UC tumour and showed patterns of LOH consistent with tumorigenesis from monoclonal tumour origin. One of five (20%) patients exhibited a LOH consistent with oligoclonal tumorigenesis. Conclusion These findings suggest that both the monoclonal and field cancerization theory of tumorigenesis may play a role in tumors of the urothelial tract. However, more data is needed. |
| ArticleNumber | 412 |
| Author | Wang, Yuding Izawa, Jonathan I Pin, Christopher L Lang, Michael R |
| Author_xml | – sequence: 1 givenname: Yuding surname: Wang fullname: Wang, Yuding organization: Department of Surgery, The Schulich School of Medicine and Dentistry, London Health Sciences Centre-Victoria Hospital London, The University of Western Ontario – sequence: 2 givenname: Michael R surname: Lang fullname: Lang, Michael R organization: Department of Surgery, The Schulich School of Medicine and Dentistry, London Health Sciences Centre-Victoria Hospital London, The University of Western Ontario – sequence: 3 givenname: Christopher L surname: Pin fullname: Pin, Christopher L organization: Divisions of Pediatrics, The Schulich School of Medicine and Dentistry, London Health Sciences Centre-Victoria Hospital London, The University of Western Ontario – sequence: 4 givenname: Jonathan I surname: Izawa fullname: Izawa, Jonathan I email: jonathan.izawa@lhsc.on.ca organization: Department of Surgery, The Schulich School of Medicine and Dentistry, London Health Sciences Centre-Victoria Hospital London, The University of Western Ontario, Divisions of Urology and Surgical Oncology, The Schulich School of Medicine and Dentistry, London Health Sciences Centre-Victoria Hospital London, The University of Western Ontario, London Health Sciences Centre-Victoria Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24024098$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_diagnostics13010153 crossref_primary_10_1038_nrc_2017_102 crossref_primary_10_1186_s13000_019_0874_5 crossref_primary_10_1080_14737159_2018_1549490 crossref_primary_10_3109_0886022X_2016_1155392 crossref_primary_10_1016_j_prp_2021_153584 crossref_primary_10_1016_j_juro_2015_01_073 crossref_primary_10_23736_S0393_2249_19_03311_3 crossref_primary_10_1016_j_purol_2014_06_010 crossref_primary_10_1016_j_urolonc_2020_01_008 crossref_primary_10_3390_jcm8071059 crossref_primary_10_1158_1078_0432_CCR_18_2039 crossref_primary_10_1016_j_eururo_2014_11_035 crossref_primary_10_1007_s10147_020_01785_9 |
| Cites_doi | 10.1016/0140-6736(93)92066-3 10.1002/ijc.10544 10.1097/00005392-200102000-00092 10.1016/j.eururo.2006.11.025 10.1016/j.canlet.2010.03.004 10.1080/03008880802291915 10.1038/labinvest.3780074 10.1038/sj.onc.1204671 10.1159/000055919 10.1016/j.cancergencyto.2010.03.007 10.1016/S0002-9440(10)65318-7 10.1002/cncr.11691 10.1056/NEJM199203123261104 10.1016/S0022-5347(01)65550-2 10.1097/01.ju.0000100105.27708.6c 10.1200/JCO.2012.45.2128 10.1111/j.1442-2042.2005.01155.x 10.1158/1078-0432.CCR-05-0891 10.1586/14737140.8.1.75 10.1016/j.eururo.2011.05.064 10.1093/carcin/19.5.855 |
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| Keywords | Transitional cell carcinoma Urothelial carcinoma Bladder cancer Upper urinary tract cancer |
| Language | English |
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To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding... To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of the... Purpose To identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding... PURPOSETo identify the origin of synchronous and metachronous urothelial carcinoma (UC) of the bladder and upper urinary tract to get a better understanding of... |
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| Title | Comparison of the clonality of urothelial carcinoma developing in the upper urinary tract and those developing in the bladder |
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