Treating KRAS-mutant NSCLC: latest evidence and clinical consequences

• Published in: Therapeutic Advances in Medical Oncology Vol. 9; no. 9; pp. 589 - 597
• Main Authors: Garrido, Pilar, Olmedo, María Eugenia, Gómez, Ana, Paz Ares, Luis, López-Ríos, Fernando, Rosa-Rosa, Juan Manuel, Palacios, José
• Format: Book Review Journal Article
• Language: English
• Published: London, England SAGE Publications 01-09-2017; Sage Publications Ltd
• Subjects: Genomics; Immune checkpoint inhibitors; K-Ras protein; Lung cancer; Mutants; Mutation; Non-small cell lung carcinoma; Reviews; Small cell lung carcinoma; non-small cell lung cancer; genomic profiling; KRAS; prognostic factor; predictive factor
• ISSN: 1758-8359; 1758-8340; 1758-8359
• DOI: 10.1177/1758834017719829

KRAS mutations represent one of the most prevalent oncogenic driver mutations in non-small cell lung cancer (NSCLC). For many years we have unsuccessfully addressed KRAS mutation as a unique disease. The recent widespread use of comprehensive genomic profiling has identified different subgroups with prognostic implications. Moreover, recent data recognizing the distinct biology and therapeutic vulnerabilities of different KRAS subgroups have allowed us to explore different treatment approaches. Small molecules that selectively inhibit KRAS G12C or use of immune checkpoint inhibitors based on co-mutation status are some examples which anticipate that personalized treatment for this challenging disease is finally on the horizon.