Developmental change of amplitude-integrated electroencephalographic activity in preterm infants with intraventricular hemorrhage

• Published in: Early human development Vol. 89; no. 12; pp. 961 - 966
• Main Authors: Sohn, Jin A, Kim, Han-Suk, Lee, Eun Hee, Lee, Juyoung, Lee, Jin A, Choi, Chang Won, Kim, Ee-Kyung, Kim, Beyong Il, Choi, Jung-Hwan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-12-2013
• Subjects: Advanced Basic Science; Amplitude-integrated electroencephalography; Analysis of Variance; Brain - growth & development; Cohort Studies; Electroencephalography - methods; Humans; Infant, Newborn; Infant, Premature - growth & development; Intracranial Hemorrhages - physiopathology; Intraventricular hemorrhage; Longitudinal Studies; Maturation score; Neonatal and Perinatal Medicine; Preterm infant; Prospective Studies; Republic of Korea; Statistics, Nonparametric; Republic of Korea; Intraventricular hemorrhage; Preterm infant; Amplitude-integrated electroencephalography; Maturation score
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2013.09.009

Abstract Background Amplitude-integrated electroencephalography (aEEG) allows continuous brain function monitoring at bedside. Objectives This prospective cohort study was designed to longitudinally evaluate aEEG tracings at increased postmenstrual age (PMA) in preterm infants with intraventricular hemorrhage (IVH). Methods Biweekly aEEG recordings were performed on preterm infants < 32 weeks gestational age from 24 to 36 weeks PMA. The tracings were evaluated according to a scoring system adapted from Burdjalov et al. Results We analyzed 496 aEEG recordings in 105 preterm infants. The control group consisted of 42 infants with no IVH, whereas the IVH grade I, II, III, and IV groups consisted of 38, 8, 3, and 14 infants, respectively. There were significant differences in the cycling and total maturation scores among the IVH groups at 36 weeks PMA ( p = 0.010 and p = 0.006, respectively). The IVH-IV patients maintained low scores in their cycling as their PMA increased, in contrast to their continuity and amplitude scores. The risk factors affecting the aEEG maturation scores at 36 weeks PMA in the IVH-IV patients included seizure events with the administration of antiepileptic drugs and the insertion of external ventricular drains (β = − 0.679 and β = − 0.418, respectively; p = 0.003). Conclusions The low cycling scores persisted until 36 weeks PMA in the IVH-IV group.