Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold required for B cell activation. Consequently, fusions of antigens with C3d polymers have shown great potential in vaccine design. However, these lin...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in immunology Vol. 9; p. 3139
Main Authors:	Yang, Yi, Back, Catherine R, Gräwert, Melissa A, Wahid, Ayla A, Denton, Harriet, Kildani, Rebecca, Paulin, Joshua, Wörner, Kristin, Kaiser, Wolgang, Svergun, Dmitri I, Sartbaeva, Asel, Watts, Andrew G, Marchbank, Kevin J, van den Elsen, Jean M H
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 11-01-2019
Subjects:	Acyltransferases - genetics Acyltransferases - immunology adjuvant Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - genetics Animals Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - immunology Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - immunology complement Disease Models, Animal Immune Evasion Immunization Immunology Mice Mice, Knockout Models, Molecular Protein Conformation Recombinant Fusion Proteins - immunology Staphycoccus aureus Staphylococcal Infections - immunology Staphylococcal Infections - prevention & control Staphylococcal Vaccines - immunology Staphylococcus - immunology Structure-Activity Relationship vaccine vaccine Staphycoccus aureus immune evasion complement adjuvant
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!