Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain

Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain

Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent isolates linked to fatal outcomes in elderly...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology Vol. 7; p. 541
Main Authors: Calderon-Gonzalez, Ricardo, Teran-Navarro, Hector, Marimon, José María, González-Rico, Claudia, Calvo-Montes, Jorge, Frande-Cabanes, Elisabet, Alkorta-Gurrutxaga, Miriam, Fariñas, M C, Martínez-Martínez, Luis, Perez-Trallero, Emilio, Alvarez-Dominguez, Carmen
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 29-11-2016
Subjects:
Immunology
Infection Control
Listeria
Listeriosis
Vaccines Carrier
Zoonoses
Listeria
zoonoses
listeriosis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH -activated monocyte-derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Reviewed by: Olivier Dussurget, University Paris Diderot, France; Rebecca Leigh Schmidt, Upper Iowa University, USA
Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
Edited by: Laurel L. Lenz, University of Colorado Denver School of Medicine, USA
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2016.00541