Long-Term Sterilizing Immunity to Rinderpest in Cattle Vaccinated with a Recombinant Vaccinia Virus Expressing High Levels of the Fusion and Hemagglutinin Glycoproteins
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| Published in: | Journal of Virology Vol. 76; no. 2; pp. 484 - 491 |
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| Main Authors: | , , , , , , , , , |
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| AbstractList | Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a recombinant vaccinia virus vaccine (v2RVFH) that expresses both the fusion (F) and hemagglutinin (H) genes of rinderpest virus (RPV) under strong synthetic vaccinia virus promoters. v2RVFH-infected cells express high levels of the F and H glycoproteins and show extensive syncytium formation. Cattle vaccinated intramuscularly with as little as 10
3
PFU of v2RVFH and challenged 1 month later with a lethal dose of RPV were completely protected from clinical disease; the 50% protective dose was determined to be 10
2
PFU. Animals vaccinated with v2RVFH did not develop pock lesions and did not transmit the recombinant vaccinia virus to contact animals. Intramuscular vaccination of cattle with 10
8
PFU of v2RVFH provided long-term sterilizing immunity against rinderpest. In addition to being highly safe and efficacious, v2RVFH is a heat-stable, inexpensive, and easily administered vaccine that allows the serological differentiation between vaccinated and naturally infected animals. Consequently, mass vaccination of cattle with v2RVFH could eradicate rinderpest. ABSTRACT Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a recombinant vaccinia virus vaccine (v2RVFH) that expresses both the fusion (F) and hemagglutinin (H) genes of rinderpest virus (RPV) under strong synthetic vaccinia virus promoters. v2RVFH-infected cells express high levels of the F and H glycoproteins and show extensive syncytium formation. Cattle vaccinated intramuscularly with as little as 10 3 PFU of v2RVFH and challenged 1 month later with a lethal dose of RPV were completely protected from clinical disease; the 50% protective dose was determined to be 10 2 PFU. Animals vaccinated with v2RVFH did not develop pock lesions and did not transmit the recombinant vaccinia virus to contact animals. Intramuscular vaccination of cattle with 10 8 PFU of v2RVFH provided long-term sterilizing immunity against rinderpest. In addition to being highly safe and efficacious, v2RVFH is a heat-stable, inexpensive, and easily administered vaccine that allows the serological differentiation between vaccinated and naturally infected animals. Consequently, mass vaccination of cattle with v2RVFH could eradicate rinderpest. Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a recombinant vaccinia virus vaccine (v2RVFH) that expresses both the fusion (F) and hemagglutinin (H) genes of rinderpest virus (RPV) under strong synthetic vaccinia virus promoters. v2RVFH-infected cells express high levels of the F and H glycoproteins and show extensive syncytium formation. Cattle vaccinated intramuscularly with as little as 10(3) PFU of v2RVFH and challenged 1 month later with a lethal dose of RPV were completely protected from clinical disease; the 50% protective dose was determined to be 10(2) PFU. Animals vaccinated with v2RVFH did not develop pock lesions and did not transmit the recombinant vaccinia virus to contact animals. Intramuscular vaccination of cattle with 10(8) PFU of v2RVFH provided long-term sterilizing immunity against rinderpest. In addition to being highly safe and efficacious, v2RVFH is a heat-stable, inexpensive, and easily administered vaccine that allows the serological differentiation between vaccinated and naturally infected animals. Consequently, mass vaccination of cattle with v2RVFH could eradicate rinderpest. Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a recombinant vaccinia virus vaccine (v2RVFH) that expresses both the fusion (F) and hemagglutinin (H) genes of rinderpest virus (RPV) under strong synthetic vaccinia virus promoters. v2RVFH-infected cells express high levels of the F and H glycoproteins and show extensive syncytium formation. Cattle vaccinated intramuscularly with as little as 10 PFU of v2RVFH and challenged 1 month later with a lethal dose of RPV were completely protected from clinical disease; the 50% protective dose was determined to be 10 PFU. Animals vaccinated with v2RVFH did not develop pock lesions and did not transmit the recombinant vaccinia virus to contact animals. Intramuscular vaccination of cattle with 10 PFU of v2RVFH provided long-term sterilizing immunity against rinderpest. In addition to being highly safe and efficacious, v2RVFH is a heat-stable, inexpensive, and easily administered vaccine that allows the serological differentiation between vaccinated and naturally infected animals. Consequently, mass vaccination of cattle with v2RVFH could eradicate rinderpest. |
| Author | Mebratu G. Yesus Berhanu Beyene Paulo H. Verardi Shabbir Ahmad Tilahun D. Yilma Berhe G. Egziabher Leslie A. Jones Henry M. Wamwayi Fatema H. Aziz Rosemary N. Ngotho |
| AuthorAffiliation | International Laboratory of Molecular Biology for Tropical Disease Agents, Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, 1 National Veterinary Institute, Debre-Zeit, Ethiopia, 2 Kenya Agricultural Research Institute, Kikuyu, Kenya 3 |
| AuthorAffiliation_xml | – name: International Laboratory of Molecular Biology for Tropical Disease Agents, Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, 1 National Veterinary Institute, Debre-Zeit, Ethiopia, 2 Kenya Agricultural Research Institute, Kikuyu, Kenya 3 |
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| CitedBy_id | crossref_primary_10_3390_vaccines10020245 crossref_primary_10_1016_S0264_410X_03_00192_0 crossref_primary_10_1073_pnas_0409846102 crossref_primary_10_4161_hv_21080 crossref_primary_10_1016_j_vaccine_2008_09_044 crossref_primary_10_1016_S0749_0720_02_00035_X crossref_primary_10_1007_s12088_010_0026_9 crossref_primary_10_1007_s00705_010_0705_1 crossref_primary_10_1016_j_virusres_2011_09_038 crossref_primary_10_1073_pnas_1112149108 crossref_primary_10_1089_vim_2004_17_401 crossref_primary_10_1371_journal_pone_0230711 crossref_primary_10_1016_j_vaccine_2014_05_025 crossref_primary_10_1016_j_virol_2004_02_030 crossref_primary_10_1586_14760584_4_1_113 crossref_primary_10_1016_j_vetmic_2017_01_010 crossref_primary_10_1128_JVI_01446_08 crossref_primary_10_1186_1297_9716_45_24 crossref_primary_10_2903_j_efsa_2022_7071 crossref_primary_10_1016_S0378_1135_03_00201_3 crossref_primary_10_1089_jir_2013_0052 crossref_primary_10_1016_j_vaccine_2010_04_102 |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Corresponding author. Mailing address: International Laboratory of Molecular Biology for Tropical Disease Agents, Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616. Phone: (530) 752-8306. Fax: (530) 752-1354. E-mail: tdyilma@ucdavis.edu. |
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Mendeley... Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a recombinant... ABSTRACT Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a... |
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| SubjectTerms | AF gene AH gene Animals Cattle Cattle Diseases - immunology Cattle Diseases - prevention & control Cattle Diseases - virology Cells, Cultured Cercopithecus aethiops F gene Giant Cells - pathology Giant Cells - virology H gene Hemagglutinins, Viral - biosynthesis Hemagglutinins, Viral - genetics Hemagglutinins, Viral - immunology Injections, Intramuscular Morbillivirus - genetics Morbillivirus - immunology Neutralization Tests Precipitin Tests Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism Rinderpest - immunology Rinderpest - prevention & control Rinderpest - virology Rinderpest virus Survival Rate Time Factors Vaccination Vaccines and Antiviral Agents Vaccines, Synthetic - adverse effects Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccinia virus Vaccinia virus - genetics Vero Cells Viral Proteins - biosynthesis Viral Proteins - genetics Viral Proteins - immunology Viral Vaccines - adverse effects Viral Vaccines - genetics Viral Vaccines - immunology |
| Title | Long-Term Sterilizing Immunity to Rinderpest in Cattle Vaccinated with a Recombinant Vaccinia Virus Expressing High Levels of the Fusion and Hemagglutinin Glycoproteins |
| URI | http://jvi.asm.org/content/76/2/484.abstract https://www.ncbi.nlm.nih.gov/pubmed/11752138 https://search.proquest.com/docview/18219080 https://search.proquest.com/docview/71347711 https://pubmed.ncbi.nlm.nih.gov/PMC136817 |
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