New tricks of prolyl oligopeptidase inhibitors – A common drug therapy for several neurodegenerative diseases

[Display omitted] Changes in prolyl oligopeptidase (PREP) expression levels, protein distribution, and activity correlate with aging and are reported in many neurodegenerative conditions. Together with decreased neuropeptide levels observed in aging and neurodegeneration, and PREP’s ability to cleav...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 161; pp. 113 - 120
Main Authors:	Svarcbahs, Reinis, Julku, Ulrika, Kilpeläinen, Tommi, Kyyrö, Mirva, Jäntti, Maria, Myöhänen, Timo T.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01-03-2019
Subjects:	Alpha-synuclein Amyloid-beta Autophagy Neurodegeneration Serine protease Tau protein APP AD ALP PREP aSyn TRH aSyn p-S129 Autophagy Aβ PD Tau protein Neurodegeneration AAV GAP-43 ROS UPS Serine protease MPTP PK S554A-PREP Alpha-synuclein Amyloid-beta
Online Access:	Get full text
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