Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex

Hepatitis C virus (HCV) replicates its genome in a membrane-associated complex composed of viral proteins, replicating RNA, and altered cellular membranes. Determinants for membrane association of the HCV nonstructural proteins involved in genome replication have been defined. In addition, a specifi...

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Bibliographic Details
Published in:	Antiviral research Vol. 60; no. 2; pp. 103 - 109
Main Authors:	Moradpour, Darius, Gosert, Rainer, Egger, Denise, Penin, François, Blum, Hubert E., Bienz, Kurt
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier B.V 01-10-2003 Elsevier Elsevier Masson
Subjects:	Amino Acid Sequence Biochemistry, Molecular Biology Biological and medical sciences Cell Line Endoplasmic Reticulum - virology Fundamental and applied biological sciences. Psychology HCV replication complex Hepacivirus - physiology Hepacivirus - ultrastructure Hepatitis C virus Humans Intracellular Membranes - metabolism Intracellular Membranes - virology Life Sciences Membrane Proteins - metabolism Membranous web Microbiology Nonstructural proteins Protein Structure, Secondary Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RNA, Viral - metabolism Viral Nonstructural Proteins - metabolism Virology Virus Replication - physiology Membranous web HCV replication complex Nonstructural proteins Membranous space RNA Protein Virus Plasma membrane Replication Flaviviridae Genome Hepatitis C virus Hepacivirus
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Summary:	Hepatitis C virus (HCV) replicates its genome in a membrane-associated complex composed of viral proteins, replicating RNA, and altered cellular membranes. Determinants for membrane association of the HCV nonstructural proteins involved in genome replication have been defined. In addition, a specific membrane alteration, designated membranous web, was recently identified as the site of viral RNA synthesis and, therefore, represents the HCV replication complex. These findings add to our current understanding of the HCV life cycle and may ultimately allow to design novel antiviral strategies against hepatitis C.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0166-3542 1872-9096
DOI:	10.1016/j.antiviral.2003.08.017