Gender differences in the expression of genes involved during cardiac development in offspring from dams on high fat diet

Previously we have demonstrated that maternal high fat diet (HF) during pregnancy increase cardiovascular risk in the offspring, and pharmacological intervention using statins in late pregnancy reduced these risk factors. However the effects of maternal HF-feeding and statin treatment during pregnan...

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Bibliographic Details
Published in:	Molecular biology reports Vol. 41; no. 11; pp. 7209 - 7216
Main Authors:	Elahi, Maqsood M, Matata, Bashir M
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer-Verlag 01-11-2014 Springer Netherlands Springer Nature B.V
Subjects:	adulthood adults Analysis of Variance Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Blood Pressure - drug effects brain cell cycle conception Cornified Envelope Proline-Rich Proteins - metabolism Cyclin G1 - metabolism Diet Diet, High-Fat DNA Primers - genetics drinking water Female females gender differences Gene expression Gene Expression Regulation, Developmental - physiology genes Heart Heart - embryology Heart Ventricles - metabolism high fat diet Histology lactation Life Sciences Male males maternal effect Maternal Exposure messenger RNA Mice Mice, Inbred C57BL Morphology Natriuretic Peptide, Brain - metabolism natriuretic peptides Oils & fats Organ Size - drug effects Pravastatin - administration & dosage Pravastatin - pharmacology Pregnancy Prenatal development progeny Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction risk risk factors Rodents Sex Characteristics Statins stress response weaning Developmental programming Blood pressure HMG-CoA reductase inhibition Cardiovascular dysfunction
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