Latent tuberculosis infection and tuberculosis in children and adolescents

• Published in: Einstein (São Paulo, Brazil) Vol. 16; no. 3; p. eAO4090
• Main Authors: Ishikawa, Cassia Satsuki, Matsuo, Olivia Mari, Sarno, Flavio
• Format: Journal Article
• Language: English
• Published: Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein 17-09-2018
• Subjects: Adolescent; Age Distribution; Brazil - epidemiology; Child; Child, Preschool; Criança; Female; Humans; Infant; Latent Tuberculosis - diagnosis; Latent Tuberculosis - epidemiology; Male; MEDICINE, GENERAL & INTERNAL; Mycobacterium tuberculosis; Mycobacterium tuberculosis - isolation & purification; Original; Radiography, Thoracic; Retrospective Studies; Saúde da criança; Serviços de saúde da criança; Sex Distribution; Statistics, Nonparametric; Tomography Scanners, X-Ray Computed; Tuberculin Test - statistics & numerical data; Tuberculose; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - epidemiology; Tuberculosis; Mycobacterium tuberculosis; Serviços de saúde da criança; Child health; Tuberculose; Saúde da criança; Child; Child health services; Criança
• ISSN: 1679-4508; 2317-6385; 2317-6385
• DOI: 10.1590/S1679-45082018AO4090

To describe the characteristics of patients diagnosed with tuberculosis and latent tuberculosis infection.
A retrospective study, between 2012 and 2015, with data from patients of Programa Einstein na Comunidade de Paraisópolis. To evaluate possible factors associated with patient's sex and diagnoses of tuberculosis and latent tuberculosis infection, χ2 or Fisher's exact tests were used for qualitative variables, and Mann-Whitney test for quantitative or ordinal qualitative variables.
A total of 77 patients were evaluated. Age ranged from 6 months to 13.4 years, with a majority of males (54.5%), aged zero to 4 years (54.5%), diagnosed with latent tuberculosis infection (64.9%), and classified as eutrophic (71.2%). The tuberculin test was positive in 92% and in most cases the values were above 10mm (68.0%). Approximately three-quarters of chest X-ray tests were normal (72.7%). After chest X-ray, computed tomography of thorax was the most ordered exam (29.9%), followed by smear and culture for Mycobacterium tuberculosis in the gastric aspirate (28.6%). The frequencies of altered chest X-ray (70.4% versus 4.0%), computed tomography of thorax requests (55.6% versus 16.0%) and other tests requested (81.5% versus 38.0%) were significantly higher in patients with a diagnosis of tuberculosis, relative to those with latent tuberculosis infection, respectively.
In our sample, proportions of altered chest X-ray, and performing computed tomography of thorax and other tests in patients diagnosed with tuberculosis were higher than in those with latent tuberculosis infection.