Acute Kidney Injury and Pediatric Bone Health

Acute Kidney Injury and Pediatric Bone Health

Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism-including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho-its direct e...

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Bibliographic Details
Published in:Frontiers in pediatrics Vol. 8; p. 635628
Main Authors: Hegde, Anisha, Denburg, Michelle R, Glenn, Dorey A
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 09-02-2021
Subjects:
AKI
fibroblast growth factor 23
klotho
parathyroid hormone
Pediatrics
skeleton
vitamin D
klotho
parathyroid hormone
skeleton
inflammation
fibroblast growth factor 23
vitamin D
mineral
AKI
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Summary:Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism-including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho-its direct effects on the skeletal system of children and adolescents remain largely unexplored. In this review, the pathophysiology of dysregulated mineral metabolism in AKI and its potential effects on skeletal health are discussed, including data associating AKI with fracture risk.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by: Katja Michelle Gist, Children's Hospital Colorado, United States
Reviewed by: David Selewski, University of South Carolina, United States; Marissa DeFreitas, University of Miami, United States
This article was submitted to Pediatric Nephrology, a section of the journal Frontiers in Pediatrics
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2020.635628