Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling

During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types. As these different cell types are born they progress from newly specified cells to fully differentiated neurons and glia. In order to define...

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Published in:	Journal of comparative neurology (1911) Vol. 502; no. 6; pp. 1047 - 1065
Main Authors:	Trimarchi, Jeffrey M., Stadler, Michael B., Roska, Botond, Billings, Nathan, Sun, Ben, Bartch, Brandon, Cepko, Constance L.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 20-06-2007
Subjects:	amacrine Amacrine Cells - cytology Amacrine Cells - metabolism Animals Cell Differentiation - genetics Cells, Cultured ganglion Gene Expression Profiling - methods Gene Expression Regulation, Developmental - genetics Genetic Markers - genetics In Situ Hybridization, Fluorescence Mice microarray molecular markers Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurofilament Proteins - biosynthesis Neurofilament Proteins - genetics retina Retina - cytology Retina - embryology Retina - metabolism Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Retinal Rod Photoreceptor Cells - cytology Retinal Rod Photoreceptor Cells - metabolism single cell Stem Cells - cytology Stem Cells - metabolism Transcription Factor AP-2 - genetics Transcription, Genetic - genetics
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Abstract	During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types. As these different cell types are born they progress from newly specified cells to fully differentiated neurons and glia. In order to define the developmental processes of individual cell types, single cell expression profiling was carried out on developing ganglion and amacrine cells of the murine retina. Individual cells from multiple developmental stages were isolated and profiled on Affymetrix oligonucleotide arrays. Two‐color fluorescent in situ hybridization on dissociated retinas was used to verify and extend the microarray results by allowing quantitative measurements of a large number of cells coexpressing two genes. Together, these experiments have yielded an expanded view of the processes underway in developing retinal ganglion and amacrine cells, as well as several hundred new marker genes for these cell types. In addition, this study has allowed for the definition of some of the molecular heterogeneity both between developing ganglion and amacrine cells and among subclasses of each cell type. J. Comp. Neurol. 502:1047–1065, 2007. © 2007 Wiley‐Liss, Inc.
AbstractList	During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types. As these different cell types are born they progress from newly specified cells to fully differentiated neurons and glia. In order to define the developmental processes of individual cell types, single cell expression profiling was carried out on developing ganglion and amacrine cells of the murine retina. Individual cells from multiple developmental stages were isolated and profiled on Affymetrix oligonucleotide arrays. Two‐color fluorescent in situ hybridization on dissociated retinas was used to verify and extend the microarray results by allowing quantitative measurements of a large number of cells coexpressing two genes. Together, these experiments have yielded an expanded view of the processes underway in developing retinal ganglion and amacrine cells, as well as several hundred new marker genes for these cell types. In addition, this study has allowed for the definition of some of the molecular heterogeneity both between developing ganglion and amacrine cells and among subclasses of each cell type. J. Comp. Neurol. 502:1047–1065, 2007. © 2007 Wiley‐Liss, Inc. During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types. As these different cell types are born they progress from newly specified cells to fully differentiated neurons and glia. In order to define the developmental processes of individual cell types, single cell expression profiling was carried out on developing ganglion and amacrine cells of the murine retina. Individual cells from multiple developmental stages were isolated and profiled on Affymetrix oligonucleotide arrays. Two-color fluorescent in situ hybridization on dissociated retinas was used to verify and extend the microarray results by allowing quantitative measurements of a large number of cells coexpressing two genes. Together, these experiments have yielded an expanded view of the processes underway in developing retinal ganglion and amacrine cells, as well as several hundred new marker genes for these cell types. In addition, this study has allowed for the definition of some of the molecular heterogeneity both between developing ganglion and amacrine cells and among subclasses of each cell type.
Author	Sun, Ben Roska, Botond Cepko, Constance L. Stadler, Michael B. Trimarchi, Jeffrey M. Bartch, Brandon Billings, Nathan
Author_xml	– sequence: 1 givenname: Jeffrey M. surname: Trimarchi fullname: Trimarchi, Jeffrey M. organization: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 – sequence: 2 givenname: Michael B. surname: Stadler fullname: Stadler, Michael B. organization: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland – sequence: 3 givenname: Botond surname: Roska fullname: Roska, Botond organization: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland – sequence: 4 givenname: Nathan surname: Billings fullname: Billings, Nathan organization: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 – sequence: 5 givenname: Ben surname: Sun fullname: Sun, Ben organization: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 – sequence: 6 givenname: Brandon surname: Bartch fullname: Bartch, Brandon organization: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 – sequence: 7 givenname: Constance L. surname: Cepko fullname: Cepko, Constance L. email: cepko@genetics.med.harvard.edu organization: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
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Snippet	During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types....
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SubjectTerms	amacrine Amacrine Cells - cytology Amacrine Cells - metabolism Animals Cell Differentiation - genetics Cells, Cultured ganglion Gene Expression Profiling - methods Gene Expression Regulation, Developmental - genetics Genetic Markers - genetics In Situ Hybridization, Fluorescence Mice microarray molecular markers Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurofilament Proteins - biosynthesis Neurofilament Proteins - genetics retina Retina - cytology Retina - embryology Retina - metabolism Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Retinal Rod Photoreceptor Cells - cytology Retinal Rod Photoreceptor Cells - metabolism single cell Stem Cells - cytology Stem Cells - metabolism Transcription Factor AP-2 - genetics Transcription, Genetic - genetics
Title	Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling
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