Insulin-Like Growth Factor I Inhibits Alveolar Bone Loss Following Tooth Extraction in Rats
Background Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites. Purpose To investigate the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous i...
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| Published in: | Clinical implant dentistry and related research Vol. 17; no. 6; pp. 1174 - 1179 |
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| Main Authors: | , , , , , , |
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Blackwell Publishing Ltd
01-12-2015
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| Abstract | Background
Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites.
Purpose
To investigate the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of human recombinant insulin‐like growth factor I (IGF‐I).
Materials and Methods
Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats (n = 7) received a continuous subcutaneous infusion of human recombinant IGF‐I (320 mg/day) for 3 weeks by osmotic minipump. Control animals were treated with saline via the same method (n = 7). All rats were then housed for an additional 3 weeks. Micro‐CT scanning was performed immediately after tooth extraction and at 1, 2, 3, and 6 weeks after extraction.
Results
New bone formation was markedly higher in the IGF‐I‐treated group as compared with the control group. The loss in alveolar ridge height in the IGF‐I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side.
Conclusions
IGF‐I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction. |
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| AbstractList | Background Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites. Purpose To investigate the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of human recombinant insulin-like growth factor I (IGF-I). Materials and Methods Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats (n=7) received a continuous subcutaneous infusion of human recombinant IGF-I (320mg/day) for 3 weeks by osmotic minipump. Control animals were treated with saline via the same method (n=7). All rats were then housed for an additional 3 weeks. Micro-CT scanning was performed immediately after tooth extraction and at 1, 2, 3, and 6 weeks after extraction. Results New bone formation was markedly higher in the IGF-I-treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side. Conclusions IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction. Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites. To investigate the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of human recombinant insulin-like growth factor I (IGF-I). Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats (n = 7) received a continuous subcutaneous infusion of human recombinant IGF-I (320 mg/day) for 3 weeks by osmotic minipump. Control animals were treated with saline via the same method (n = 7). All rats were then housed for an additional 3 weeks. Micro-CT scanning was performed immediately after tooth extraction and at 1, 2, 3, and 6 weeks after extraction. New bone formation was markedly higher in the IGF-I-treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side. IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction. Background Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites. Purpose To investigate the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of human recombinant insulin‐like growth factor I (IGF‐I). Materials and Methods Fourteen rats were subjected to right mandibular first molar extraction. Experimental rats (n = 7) received a continuous subcutaneous infusion of human recombinant IGF‐I (320 mg/day) for 3 weeks by osmotic minipump. Control animals were treated with saline via the same method (n = 7). All rats were then housed for an additional 3 weeks. Micro‐CT scanning was performed immediately after tooth extraction and at 1, 2, 3, and 6 weeks after extraction. Results New bone formation was markedly higher in the IGF‐I‐treated group as compared with the control group. The loss in alveolar ridge height in the IGF‐I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side. Conclusions IGF‐I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction. BACKGROUNDAlveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites.PURPOSETo investigate the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of human recombinant insulin-like growth factor I (IGF-I).MATERIALS AND METHODSFourteen rats were subjected to right mandibular first molar extraction. Experimental rats (n = 7) received a continuous subcutaneous infusion of human recombinant IGF-I (320 mg/day) for 3 weeks by osmotic minipump. Control animals were treated with saline via the same method (n = 7). All rats were then housed for an additional 3 weeks. Micro-CT scanning was performed immediately after tooth extraction and at 1, 2, 3, and 6 weeks after extraction.RESULTSNew bone formation was markedly higher in the IGF-I-treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side.CONCLUSIONSIGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction. |
| Author | Shoji, Noriaki Sasano, Takashi Kumasaka, Akira Nishioka, Takashi Iikubo, Masahiro Kojima, Ikuho Sakamoto, Maya |
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Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these... Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these extraction sites.... BACKGROUNDAlveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these... Background Alveolar bone is often lost after tooth extraction. Few studies have assessed the longitudinal changes in bone volume that occur within these... |
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| SubjectTerms | Alveolar Bone Loss - diagnostic imaging Alveolar Bone Loss - pathology Alveolar Bone Loss - prevention & control Animals Dentistry healing Humans IGF-I Insulin-Like Growth Factor I - pharmacology Male mandible Mandible - diagnostic imaging micro-CT Molar - surgery morphological change Osteogenesis - drug effects Rats Rats, Wistar Tooth Extraction Tooth Socket - pathology X-Ray Microtomography |
| Title | Insulin-Like Growth Factor I Inhibits Alveolar Bone Loss Following Tooth Extraction in Rats |
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