Rodent nonclinical safety evaluation studies of SCH 58500, an adenoviral vector for the p53 gene

SCH 58500 is a replication-defective recombinant adenoviral vector containing the cloned human wild-type (normal) tumor suppressor gene p53. SCH 58500 is in trials to evaluate potential clinical utility. A series of toxicology studies in rats and mice were conducted via multiple routes of exposure t...

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Bibliographic Details
Published in:	Toxicological sciences Vol. 65; no. 2; pp. 266 - 275
Main Authors:	MORRISSEY, Richard E, HORVATH, Christopher, SNYDER, Eileen A, PATRICK, James, MACDONALD, James S
Format:	Journal Article
Language:	English
Published:	Cary, NC Oxford University Press 01-02-2002
Subjects:	Adenoviridae - genetics Adenoviridae - growth & development Animals Antibodies, Viral - blood Biological and medical sciences Blood Coagulation - drug effects Defective Viruses Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Female Genes, p53 Genetic Vectors - toxicity Hemagglutination Tests Kidney - drug effects Liver - drug effects Male Medical sciences Mice Mice, Inbred ICR Miscellaneous (drug allergy, mutagens, teratogens...) Other treatments Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Safety Toxicity Tests Treatment. General aspects Tumors Antineoplastic agent Intraperitoneal administration Intravenous administration Rat Toxicity Sex Drug carrier Hemopathy Route of administration Blood Tissue TP53 Gene Subcutaneous administration Tumor suppressor gene Acute Rodentia Genetic transfer Toxicokinetics Vertebrata Chronic Mammalia Mouse Animal Distribution Kinetics Gene therapy Coagulopathy
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