Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administrati...

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Bibliographic Details
Published in:	Antioxidants Vol. 10; no. 11; p. 1783
Main Authors:	Rodríguez-Pérez, María Dolores, López-Villodres, Juan Antonio, Arrebola, María Monsalud, Martín-Aurioles, Esther, Fernández-Prior, África, Bermúdez-Oria, Alejandra, Ríos, María Carmen, De La Cruz, José Pedro, González-Correa, José Antonio
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 08-11-2021 MDPI
Subjects:	Acids Antioxidants Biomarkers Chromatography Creatinine Diabetes Diabetes mellitus (insulin dependent) Diabetic retinopathy Enzymes Glucose hydroxytyrosol Hyperglycemia Immunoassay Kidney diseases Kidneys Laboratory animals Mortality nephropathy Olive oil Oral administration Oxidative stress Proteinuria Streptozocin Urine virgin olive oil United States > US Madrid Spain Spain
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Summary:	The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67–73%), calculated creatinine clearance was significantly increased (26–38%), and the glomerular volume and glomerulosclerosis index were decreased (20–30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work.
ISSN:	2076-3921 2076-3921
DOI:	10.3390/antiox10111783