Incidence, Predictors, Costs, and Outcome of Renal Cell Carcinoma After Kidney Transplantation: USRDS Experience

• Published in: Transplantation Vol. 90; no. 8; pp. 898 - 904
• Main Authors: HURST, Frank P, JINDAL, Rahul M, GRAHAM, Lindsey J, FALTA, Edward M, ELSTER, Eric A, STACKHOUSE, George B, AGODOA, Lawrence Y, LENTINE, Krista L, SALIFU, Moro O, ABBOTT, Kevin C
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 27-10-2010
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Carcinoma, Renal Cell - economics; Carcinoma, Renal Cell - epidemiology; Carcinoma, Renal Cell - etiology; Child; Child, Preschool; Cohort Studies; Costs and Cost Analysis; Databases, Factual; Epidemiology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; Humans; Incidence; Infant; Kaplan-Meier Estimate; Kidney Diseases, Cystic - complications; Kidney Neoplasms - economics; Kidney Neoplasms - epidemiology; Kidney Neoplasms - etiology; Kidney Transplantation - adverse effects; Male; Medical sciences; Medicare; Middle Aged; Prognosis; Proportional Hazards Models; Public health. Hygiene; Public health. Hygiene-occupational medicine; Retrospective Studies; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Tissue, organ and graft immunology; United States - epidemiology; Young Adult; United States; Costs; Carcinoma; Prognosis; Homotransplantation; Epidemiology; Kidney; Incidence; Surgery; Evolution; Graft; Grawitz tumor; Public health; Kidney disease; Urinary system disease; Prediction; Malignant tumor; Experience; Treatment; Urinary system; Health economy; Kidney cancer; Economic aspect; Predictive factor; Cancer; Kidney transplantation
• ISSN: 0041-1337; 1534-6080
• DOI: 10.1097/TP.0b013e3181f30479

We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors, prognosis, and costs associated with the diagnosis of renal cell carcinoma (RCC) after kidney transplantation.
This is a retrospective cohort of 40,821 Medicare primary renal transplant recipients transplanted from January 1, 2000, to July 1, 2005, and followed up till December 31, 2005, excluding those with prior RCC or nephrectomy. Kaplan-Meier analysis was performed to determine the time of occurrence of RCC, and Cox regression was used to determine factors associated with RCC.
Three hundred sixty-eight patients were diagnosed with RCC within 3 years after transplant (incidence of 3.16 per 1000 person years). The 3-year incidence of RCC posttransplant was 9.29 per 1000 person years (2.3%) for those with pretransplant cysts and 3.08 per 1000 person years (0.7%) without pretransplant cysts. RCC was diagnosed disproportionately early posttransplant in patients with cysts. Cysts were independently associated with increased risk of RCC, as was male gender, older recipient, donor age, African American recipient, increased time on dialysis and acute rejection within first year posttransplant. RCC was associated with increased risk of mortality with a higher risk with pretransplant cysts. Patients who developed RCC had higher cumulative median costs ($55,456 at 2 years) than those who did not develop RCC ($40,369). There was no "clustering" of RCC in individual states or centers more than would be expected by chance.
RCC was diagnosed disproportionately early in patients with pretransplant renal cysts and was associated with a worse prognosis and increased costs.