Effects of landiolol on the cardiovascular response during tracheal extubation

• Published in: Journal of anesthesia Vol. 22; no. 3; pp. 322 - 325
• Main Authors: Shirasaka, Tetsuro, Iwasaki, Tatsuma, Hosokawa, Nobuko, Komatsu, Miki, Kasaba, Toshiharu, Takasaki, Mayumi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 2008
• Subjects: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesiology; Anti-Arrhythmia Agents - pharmacology; Blood Pressure - drug effects; Critical Care Medicine; Emergency Medicine; Female; Heart Rate - drug effects; Humans; Intensive; Intubation, Intratracheal; Male; Medicine; Medicine & Public Health; Middle Aged; Morpholines - pharmacology; Pain Medicine; Short Communication; Time Factors; Urea - analogs & derivatives; Urea - pharmacology; Young Adult; Landiolol; Extubation; Hemodynamic response
• ISSN: 0913-8668; 1438-8359
• DOI: 10.1007/s00540-008-0621-7

The objective of this study was to investigate the effect of landiolol on the cardiovascular responses to emergence from anesthesia and tracheal extubation. Fifty-nine patients without cardiovascular disorders who were scheduled for tympanoplasty were randomly allocated to receive a loading dose of landiolol at 0.125 mg·kg
−1
·min
−1
for 1 min, followed by an infusion at 0.01 mg·kg
−1
·min
−1
(group L1), 0.02 mg·kg
−1
·min
−1
(group L2), 0.03 mg·kg
−1
·min
−1
(group L3), or 0.04 mg·kg
−1
·min
−1
(group L4). At the end of surgery, sevoflurane and nitrous oxide were discontinued, and landiolol was started. The mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) in the four groups were compared before anesthesia induction, just after extubation, 5 min after extubation, 10 min after extubation, and at discharge from the operating room. Just after extubation compared with the baseline, the MAP increased significantly in all groups; the HR increased in groups L1 and L2; and the RPP increased in all groups, except for group L4. Continuous administration of landiolol, at 0.03 or 0.04 mg·kg
−1
·min
−1
, may prevent the increases in HR and RPP, respectively, that occur at the emergence from anesthesia and tracheal extubation.