Phyllodes tumours of the breast: A clinicopathological analysis of 65 cases from a single institution

• Published in: Breast (Edinburgh) Vol. 18; no. 3; pp. 165 - 170
• Main Authors: Karim, R.Z, Gerega, S.K, Yang, Y.H, Spillane, A, Carmalt, H, Scolyer, R.A, Lee, C.S
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-06-2009
• Subjects: Aged; Breast; Breast Neoplasms - epidemiology; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Female; Fibroadenoma; Fibroepithelial tumour; Hematology, Oncology and Palliative Medicine; Humans; Mastectomy - statistics & numerical data; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Neoplasm Staging - statistics & numerical data; New South Wales - epidemiology; Pathology; Phyllodes Tumor - epidemiology; Phyllodes Tumor - pathology; Phyllodes Tumor - surgery; Phyllodes tumour; Survival Analysis; Treatment Outcome; Women's Health; New South Wales; Breast; Pathology; Fibroepithelial tumour; Fibroadenoma; Phyllodes tumour
• ISSN: 0960-9776; 1532-3080
• DOI: 10.1016/j.breast.2009.03.001

Abstract The aim of this study was to document the clinical and pathological features of a large single institutional series of ethnically diverse patients with phyllodes tumours (PTs), and to determine which characteristics were predictive of outcome. Sixty five PTs were analysed; 34 were benign, 23 borderline and eight malignant (34 low grade and 31 high grade PTs on a two tiered grading system). Nine patients (15%) had local recurrences. A greater percentage of higher grade tumours recurred and women of Asian origin had a higher recurrence rate compared to the non-Asian patients. The 5 year disease-free survival was 81% and time to recurrence was significantly lower in the high grade group. No metastases or deaths from disease were recorded. The mean age at diagnosis significantly increased with tumour grade. The mean tumour volume also significantly increased with grade. Tumour grade was the only parameter related significantly to outcome.