Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines

Purpose The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for metastasis. The aim of this study was to elucidate the effects of low-dose TRD on pancreatic ca...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of colorectal disease Vol. 29; no. 11; pp. 1339 - 1348
Main Authors:	Hotz, Birgit, Erben, Ulrike, Arndt, Marco, Buhr, Heinz J., Hotz, Hubert G.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2014 Springer Springer Nature B.V
Subjects:	Analysis Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cadherins - genetics Cancer Cell Adhesion - drug effects Cell Line, Tumor Cell Survival - drug effects Development and progression Dose-Response Relationship, Drug Epithelial-Mesenchymal Transition - drug effects Ethylenediaminetetraacetic acid G1 Phase Cell Cycle Checkpoints - drug effects G2 Phase Cell Cycle Checkpoints - drug effects Gastroenterology Hepatology Humans Internal Medicine Medicine Medicine & Public Health Metastasis Neoplasm Metastasis Oncology, Experimental Original Article Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Povidone Proctology Snail Family Transcription Factors Stem cells Surgery Taurine Taurine - administration & dosage Taurine - analogs & derivatives Taurine - pharmacology Thiadiazines - administration & dosage Thiadiazines - pharmacology Transcription Factors - genetics Up-Regulation Snail EMT Pancreatic cancer Taurolidine Apoptosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!