Technique of spinal cord compression induced by inflation of epidural balloon catheter in rabbits (Oryctologus cuniculus): efficient and easy to use model

• Published in: Anais da Academia Brasileira de Ciências Vol. 88; no. 3; pp. 1511 - 1517
• Main Authors: Fonseca, Antonio F B DA, Scheffer, Jussara P, Coelho, Barbara P, Aiello, Graciane, Guimarães, Arthur G, Gama, Carlos R B, Vescovini, Victor, Cabral, Paula G A, Oliveira, André L A
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Ciências 01-09-2016
• Subjects: Animals; Catheters; Disease Models, Animal; Epidural Space; experimental; MULTIDISCIPLINARY SCIENCES; neuro-traumatology; paraplegia; Rabbits; Reproducibility of Results; Spinal Cord Compression - etiology; experimental; paraplegia; neuro-traumatology; rabbits
• ISSN: 0001-3765; 1678-2690; 1678-2690
• DOI: 10.1590/0001-3765201620160060

The most common cause of spinal cord injury are high impact trauma, which often result in some motor impairment, sensory or autonomic a greater or lesser extent in the distal areas the level of trauma. In terms of survival and complications due to sequelae, veterinary patients have a poor prognosis unfavorable. Therefore justified the study of experimental models of spinal cord injury production that could provide more support to research potential treatments for spinal cord injuries in medicine and veterinary medicine. Preclinical studies of acute spinal cord injury require an experimental animal model easily reproducible. The most common experimental animal model is the rat, and several techniques for producing a spinal cord injury. The objective of this study was to describe and evaluate the effectiveness of acute spinal cord injury production technique through inflation of Fogarty(r) catheter using rabbits as an experimental model because it is a species that has fewer conclusive publications and contemplating. The main requirements of a model as low cost, handling convenience, reproducibility and uniformity. The technique was adequate for performing preclinical studies in neuro-traumatology area, effectively leading to degeneration and necrosis of the nervous tissue fostering the emergence of acute paraplegia.